Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2020 May;26(4):733-744.
doi: 10.1111/odi.13140. Epub 2019 Jul 15.

Oral cancer-associated fibroblasts predict poor survival: Systematic review and meta-analysis

Diana Graizel  1 , Ayelet Zlotogorski-Hurvitz  2   3 , Igor Tsesis  4 , Eyal Rosen  4 , Ron Kedem  5 , Marilena Vered  2   6
Affiliations
Meta-Analysis

Oral cancer-associated fibroblasts predict poor survival: Systematic review and meta-analysis

Diana Graizel et al. Oral Dis. 2020 May.

Abstract

Objectives: To perform systematic review and meta-analysis on correlations between cancer-associated fibroblasts (CAFs) and the risk of death for patients with oral squamous cell carcinoma.

Subjects and methods: English literature (1966-2018) was systematically analyzed for studies that immunohistochemically assessed CAF density by alpha-smooth muscle actin and presented 5 year survival rates by Kaplan-Meier plots. Mean age of patients, proportion of male/female patients, and male/female majority (>50% male/female patients) per study were also collected. Significance level for statistical models was p < 0.05.

Results: Meta-analysis comprised 11 studies/1,040 patients. Univariate Cox regressions showed that high CAF density was a negative prognostic factor in studies with female and male majority [OR 5.329 (95% CI 3.223-8.811), p < 0.001, and OR 2.208 (95% CI 1.717-2.839), p < 0.001, respectively]. High CAF density with male majority was associated with a more favorable prognosis [OR 0.996 (95% CI 0.979-1.013), p < 0.001]. Multivariate Cox regressions showed that death risk was significantly higher among patients with high CAF density compared to low CAF [OR 2.741 (95% CI 2.220-3.384) p < 0.001]. High mean age and male proportion were significantly protective [OR 0.940 (95% CI 0.925-9.955), p < 0.001, OR 0.125 (95% CI 0.018-0.867), p = 0.035), respectively].

Conclusions: CAFs increased death risk, male majority, and higher mean age were protective. A clinically validated cutoff for CAF density could serve as a reliable prognostic tool.

Keywords: age; cancer-associated fibroblasts; gender; oral cancer; prognosis; survival.

PubMed Disclaimer

References

REFERENCES

    1. Bae, J. Y., Kim, E. K., Yang, D. H., Zhang, X., Park, Y.-J., Lee, D. Y., … Kim, J. (2014). Reciprocal interaction between carcinoma-associated fibroblasts and squamous carcinoma cells through interleukin-1α induces cancer progression. Neoplasia, 16, 928-938. https://doi.org/10.1016/j.neo.2014.09.003
    1. Bello, I. O., Vered, M., Dayan, D., Dobriyan, A., Yahalom, R., Alanen, K., … Salo, T. (2011). Cancer-associated fibroblasts, a parameter of the tumor microenvironment overcomes carcinoma-associated parameters in the prognosis of patients with mobile tongue cancer. Oral Oncology, 47, 33-38. https://doi.org/10.1016/j.oraloncology.2010.10.013
    1. Blanchard, P., Belkhir, F., Temam, S., El Khoury, C., De Felice, F., Casiraghi, O., … Tao, Y. (2017). Outcomes and prognostic factors for squamous cell carcinoma of the oral tongue in young adults: A single-institution case-matched analysis. European Archives of Oto-Rhino-Laryngology, 274, 1683-1690. https://doi.org/10.1007/s00405-016-4419-1
    1. Brandwein-Gensler, M., Smith, R. V., Wang, B., Penner, C., Theilken, A., Broughel, D., … Negassa, A. (2010). Validation of the histologic risk model in a new cohort of patients with head and neck squamous cell carcinoma. The American Journal of Surgical Pathology, 34, 676-988. https://doi.org/10.1097/PAS.0b013e3181d95c37
    1. Brandwein-Gensler, M., Teixeira, M. S., Lewis, C. M., Lee, B., Rolnitzky, L., Hille, J. J., … Wang, B. Y. (2005). Oral squamous cell carcinoma: Histologic risk assessment, but not margin status, is strongly predictive of local disease-free and overall survival. The American Journal of Surgical Pathology, 29, 167-178. https://doi.org/10.1097/01.pas.0000149687.90710.21

LinkOut - more resources