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Meta-Analysis
. 2019 Jun 8;55(6):257.
doi: 10.3390/medicina55060257.

Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis

Hamid Reza Mozaffari  1   2 , Maryam Molavi  3 , Pia Lopez-Jornet  4 , Masoud Sadeghi  5 , Mohsen Safaei  6 , Mohammad Moslem Imani  7 , Roohollah Sharifi  8 , Hedaiat Moradpoor  9 , Amin Golshah  10 , Ladan Jamshidy  11
Affiliations
Meta-Analysis

Salivary and Serum Interferon-Gamma/Interleukin-4 Ratio in Oral Lichen Planus Patients: A Systematic Review and Meta-Analysis

Hamid Reza Mozaffari et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Interferon-gamma (IFN-γ)/interleukin-4 (IL-4) ratio may indicate a change in the immune response with a potential pathological effect presented in oral lichen planus (OLP) patients. Herein, this meta-analysis evaluated the role of serum and salivary interferon-gamma/interleukin-4 ratio in the severity and development of OLP. Materials and Methods: The Scopus, Cochrane Library, PubMed, and Web of Science databases were systematically searched to retrieve the relevant studies published up from the database inception to March 2019. The crude mean difference (MD) and 95% confidence interval (CI) were calculated by RevMan 5.3 software using a random-effects model. A sensitivity analysis was performed on the results using the CMA 2.0 software. A total of 98 studies were retrieved from the databases, of which at last seven studies were included in this meta-analysis. Results: The findings showed that the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were -0.22 (95% CI: -1.16, 0.72; p = 0.64) and 0.17 (95% CI: -1.50, 1.84; p = 0.84) in OLP patients compared to controls, respectively. In addition, the pooled MDs of serum and salivary IFN-γ/IL-4 ratio were -0.15 (95% CI: -0.53, 0.23; p = 0.43) and -0.39 (95% CI: -0.63, -0.15; p = 0.001) in patients with erythematous/ulcerative subtype compared to patients with reticular subtype, respectively. Conclusions: In conclusion, the results of meta-analysis demonstrated that serum and salivary IFN-γ/IL-4 ratio cannot play a major role in OLP development and severity.

Keywords: interferon-gamma; interleukin-4; meta-analysis; oral lichen planus; ratio.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow-chart of the present study.
Figure 2
Figure 2
Forest plot of serum interferon-gamma/interleukin-4 (IFN-γ/IL-4) ratio in the patients with oral lichen planus compared to the controls.
Figure 3
Figure 3
Forest plot of salivary IFN-γ/IL-4 ratio in the patients with oral lichen planus compared to the controls. Patients with erythematous/ulcerative subtype vs. reticular subtype (serum).
Figure 4
Figure 4
Forest plot of serum IFN-γ/IL-4 ratio in the patients with erythematous/ulcerative patients compared to reticular patients. Patients with erythematous/ulcerative subtype vs. reticular subtype (saliva).
Figure 5
Figure 5
Forest plot of salivary IFN-γ/IL-4 ratio in the patients with erythematous/ulcerative patients compared to reticular patients.
See this image and copyright information in PMC

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