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Case Reports
. 2019 May 6;7(6):1161-1166.
doi: 10.1002/ccr3.2176. eCollection 2019 Jun.

Variant form of hairy cell leukemia

Margaux Wiber  1 , Elsa Maitre  1   2 , Edouard Cornet  1   2 , Véronique Salaün  1 , Dina Naguib  1 , Xavier Troussard  1   2   3
Affiliations
Case Reports

Variant form of hairy cell leukemia

Margaux Wiber et al. Clin Case Rep. .

Abstract

Mature lymphoid B-cell proliferations with hairy cells represent heterogeneous entities where specific diagnosis is difficult but important since it impacts therapeutic management. The clinical cases of variant hairy cell leukemia reported herein illustrate the persistence of a clear interest in the use of splenectomy as a therapeutic alternative. Furthermore, ibrutinib appears to be a promising treatment in patients with relapsed/refractory disease.

Keywords: BRAFV600E; Ibrutinib; KDM6A; chronic B‐lymphoproliferative disorder; hairy cell leukemia; hairy cell leukemia variant.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Case 1. A, Hairy cells in peripheral blood. B, Hairy cells in bone marrow. C, Flow cytometric analysis of expression levels of CD103, CD123, CD25, and CD11c (HCL score) on hairy cells. D, Complete blood count evolution. C, cladribine; R, rituximab
Figure 2
Figure 2
Case 2. A, Hairy cells in peripheral blood. B, Hairy cells in bone marrow. C, Flow cytometric analysis of expression levels of CD103, CD123, CD25, and CD11c (HCL score) on hairy cells. D, Complete blood count evolution
See this image and copyright information in PMC

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