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. 2019 May 10;7(6):1263-1264.
doi: 10.1002/ccr3.2188. eCollection 2019 Jun.

Lysozyme nephropathy in chronic myelomonocytic leukemia

Ami B Patel  1 , Rodney R Miles  2 , Michael W Deininger  1
Affiliations

Lysozyme nephropathy in chronic myelomonocytic leukemia

Ami B Patel et al. Clin Case Rep. .

Abstract

Lysozyme nephropathy is a frequently unrecognized cause of renal disease in chronic myelomonocytic leukemia and may serve as a novel indication for treatment in this patient population. We demonstrate that in newly diagnosed CMML patients, plasma lysozyme levels are positively correlated with both absolute monocyte count and serum creatinine.

Keywords: hematology; nephrology; oncology.

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Conflict of interest statement

None declared.

Figures

Figure 1
Figure 1
Lysozyme nephropathy in CMML. A, H&E stain demonstrating bright eosinophilic cytoplasmic granules within renal proximal tubule cells. B, Lysozyme immunohistochemical stain highlighting cytoplasmic droplets within the proximal tubule. C, Correlation of absolute monocyte count of newly diagnosed CMML patients with plasma lysozyme levels. D, Correlation of plasma lysozyme levels with concurrent serum creatinine measurements
See this image and copyright information in PMC

References

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    1. Cojocel C, Dociu N, Baumann K. Early nephrotoxicity at high plasma concentrations of lysozyme in the rat. Lab Invest. 1982;46:149‐157. - PubMed

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