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. 2019 Jul;31(4):572-575.
doi: 10.1177/1040638719855682. Epub 2019 Jun 11.

Oncotic pressure and the effects of water deprivation in healthy captive Asian elephants

Natalie H Hall  1   2   3   4 , James S Hall  1   2   3   4 , Ellen Wiedner  1   2   3   4 , Nicole I Stacy  1   2   3   4 , Carsten Bandt  1   2   3   4 , Ramiro Isaza  1   2   3   4
Affiliations

Oncotic pressure and the effects of water deprivation in healthy captive Asian elephants

Natalie H Hall et al. J Vet Diagn Invest. 2019 Jul.

Abstract

We evaluated the oncotic pressure (plasma colloid osmotic pressure, πc) in a group of healthy, captive Asian elephants (Elephas maximus; n = 21) with a colloid osmometer with a membrane cutoff of >20,000 daltons. The median πc for these elephants was 26.3 mm Hg with an interquartile interval of 25.5-26.8 mm Hg. The mean πc value was 26.0 mm Hg ± SD 1.1. We found moderate correlation between albumin measured by electrophoresis and πc (r = 0.622; p = 0.003). After a 16-h water deprivation test in a subset of elephants (n = 16), a difference in πc was not detected, despite a significant increase in serum total proteins, urea, and osmolality. These results indicate that πc is not a sensitive indicator of hydration status in elephants after a short period of water deprivation. Use of oncotic pressure as a diagnostic tool in diseased Asian elephants warrants further investigation.

Keywords: colloids; elephants; hydration; oncotic pressure; plasma.

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Conflict of interest statement

Declaration of conflicting interests: The authors declared no potential conflicts of interest with respect to the research, authorship, and/or publication of this article.

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