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Comment
. 2019 Jun 10;35(6):827-829.
doi: 10.1016/j.ccell.2019.05.007.

Fatty Acids Corrupt Neutrophils in Cancer

Max D Wellenstein  1 , Karin E de Visser  2
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Free article
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Fatty Acids Corrupt Neutrophils in Cancer

Max D Wellenstein et al. Cancer Cell. .
Free article

Abstract

Understanding how tumors escape from immune attack may offer novel therapeutic opportunities. Veglia et al. (2019) demonstrate in Nature that fatty acid transport protein 2 (FATP2) endows neutrophils with immunosuppressive capabilities that promote cancer growth. This receptor can be targeted to unleash anti-tumor immunity and to potentiate immune checkpoint blockade.

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  • Fatty acid transport protein 2 reprograms neutrophils in cancer.
    Veglia F, Tyurin VA, Blasi M, De Leo A, Kossenkov AV, Donthireddy L, To TKJ, Schug Z, Basu S, Wang F, Ricciotti E, DiRusso C, Murphy ME, Vonderheide RH, Lieberman PM, Mulligan C, Nam B, Hockstein N, Masters G, Guarino M, Lin C, Nefedova Y, Black P, Kagan VE, Gabrilovich DI. Veglia F, et al. Nature. 2019 May;569(7754):73-78. doi: 10.1038/s41586-019-1118-2. Epub 2019 Apr 17. Nature. 2019. PMID: 30996346 Free PMC article.

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