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Comment
. 2019 Aug 15;25(16):4865-4867.
doi: 10.1158/1078-0432.CCR-19-1219. Epub 2019 Jun 11.

Detection of NRG1 Fusions in Solid Tumors: Rare Gold?

Anastasios Dimou  1 , D Ross Camidge  2
Affiliations
Comment

Detection of NRG1 Fusions in Solid Tumors: Rare Gold?

Anastasios Dimou et al. Clin Cancer Res. .

Abstract

Fusions between NRG1 and partner genes are rare, tumorigenic genomic events occurring in patients with lung and other cancers, associated with activation of ERBB2/ERBB3 heterodimers. Inhibition of ERBB2 and/or ERBB3 in this group of patients is a promising strategy in clinical trials.See related article by Jonna et al., p. 4966.

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  • Detection of NRG1 Gene Fusions in Solid Tumors.
    Jonna S, Feldman RA, Swensen J, Gatalica Z, Korn WM, Borghaei H, Ma PC, Nieva JJ, Spira AI, Vanderwalde AM, Wozniak AJ, Kim ES, Liu SV. Jonna S, et al. Clin Cancer Res. 2019 Aug 15;25(16):4966-4972. doi: 10.1158/1078-0432.CCR-19-0160. Epub 2019 Apr 15. Clin Cancer Res. 2019. PMID: 30988082 Free PMC article.

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