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. 2019 Jun;17(6):5681-5685.
doi: 10.3892/ol.2019.10271. Epub 2019 Apr 18.

Surgical treatment of early tongue squamous cell carcinoma and patient survival

Lansheng Zhu  1 , Yanling Wang  1 , Rui Li  2 , Aiqun Liu  1 , Xiaoping Zhang  1 , Chunran Zuo  1 , Xiaoting Xu  1
Affiliations

Surgical treatment of early tongue squamous cell carcinoma and patient survival

Lansheng Zhu et al. Oncol Lett. 2019 Jun.

Abstract

Surgical options for treating early tongue squamous cell carcinoma and patient survival were explored. Clinical records of 128 patients with early tongue squamous cell carcinoma who were treated in Henan Province Hospital of TCM from June, 2010 to June, 2013 were retrospectively analyzed. According to adopted treatment plan, the patients were divided into 3 groups: 42 patients in surgical therapy alone group, 46 patients in preoperative radiotherapy group, and 40 patients in postoperative radiotherapy group. Statistical analysis was performed on the general data of patients and clinical records, as well as the 5-year survival rate and recurrence rate. The overall 5-year survival rate for all patients was 86.7% (111/128), and the 5-year disease-specific survival rate was 88.8% (111/125). In the individual groups, the 5-year survival rate and the 5-year disease-specific survival rate were 91.3% (84/92) and 91.3% (84/92), respectively, in the surgical therapy alone group 76.9% (10/13) and 83.3% (10/12), respectively, in the preoperative radiotherapy group, and 73.9% (17/23) and 81.0% (17/21), respectively, in the postoperative radiotherapy group. There were no statistically significant differences in 5-year survival rate (χ2=5.990, P=0.051) and 5-year disease-specific survival rate (χ2=2.223, P=0.329) among the three groups. In total, there were 25 cases of recurrence during follow-up. The recurrence rate was 19.5%; the local recurrence rate was 11.7% (15/128); and the regional recurrence rate was 7.8% (10/128). There were 6 cases of metastasis, and the metastatic rate was 4.7%. There were no statistically significant differences in recurrence rate and metastatic rate among the three groups. Compared with surgical therapy alone, radiotherapy combined with surgical therapy neither improved 5-year survival rate nor reduced recurrence rate. Therefore, surgical therapy alone is suggested to be the preferred option for treating early tongue squamous cell carcinoma.

Keywords: early tongue squamous cell carcinoma; surgical treatment; survival.

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Figures

Figure 1.
Figure 1.
Disease-specific survival rates of patients in the three groups.
Figure 2.
Figure 2.
Survival rates of patients in the three groups.
See this image and copyright information in PMC

References

    1. Kelner N, Rodrigues PC, Bufalino A, Fonseca FP, Santos-Silva AR, Miguel MC, Pinto CA, Leme AF, Graner E, Salo T, et al. Activin A immunoexpression as predictor of occult lymph node metastasis and overall survival in oral tongue squamous cell carcinoma. Head Neck. 2015;37:479–486. doi: 10.1002/hed.23627. - DOI - PubMed
    1. Aparna M, Rao L, Kunhikatta V, Radhakrishnan R. The role of MMP-2 and MMP-9 as prognostic markers in the early stages of tongue squamous cell carcinoma. J Oral Pathol Med. 2015;44:345–352. doi: 10.1111/jop.12245. - DOI - PubMed
    1. Maxwell JH, Thompson LD, Brandwein-Gensler MS, Weiss BG, Canis M, Purgina B, Prabhu AV, Lai C, Shuai Y, Carroll WR, et al. Early oral tongue squamous cell carcinoma: Sampling of margins from tumor bed and worse local control. JAMA Otolaryngol Head Neck Surg. 2015;141:1104–1110. doi: 10.1001/jamaoto.2015.1351. - DOI - PMC - PubMed
    1. Thiagarajan S, Nair S, Nair D, Chaturvedi P, Kane SV, Agarwal JP, D'Cruz AK. Predictors of prognosis for squamous cell carcinoma of oral tongue. J Surg Oncol. 2014;109:639–644. doi: 10.1002/jso.23583. - DOI - PubMed
    1. Ren ZH, Wu HJ, Zhang S, Wang K, Gong ZJ, He ZJ, Peng J. A new surgical strategy for treatment of tongue squamous cell carcinoma based on anatomic study with preliminary clinical evaluation. J Craniomaxillofac Surg. 2015;43:1577–1582. doi: 10.1016/j.jcms.2015.07.034. - DOI - PubMed