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. 2019:1:100004.
doi: 10.1016/j.yrmex.2019.100004. Epub 2019 Feb 21.

Tocilizumab in sarcoidosis patients failing steroid sparing therapies and anti-TNF agents

Michelle Sharp  1 , Seamas C Donnelly  2 , David R Moller  1
Affiliations

Tocilizumab in sarcoidosis patients failing steroid sparing therapies and anti-TNF agents

Michelle Sharp et al. Respir Med X. 2019.
No abstract available

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Figures

Fig. 1.
Fig. 1.
Hypothesized therapeutic role of blocking IL6 pathway in Sarcoidosis. Innate response to microbial infection induces IL6 by macrophages and dendritic cells leading to 1. Activation of the acute phase response with induction of serum amyloid A (SAA) that aggregates within granulomas and stimulates local T cell immunity; 2. induction of mTOR with metabolic changes and promoting epithelioid cell differentiation; 3. promotion of Th17 cell differentiation; 4. inhibition of regulatory T cell differentiation enhancing local Th1/ Th17/Th17.1 immunity. Blocking IL6 receptor with tocilizumab would potentially inhibit these responses.
See this image and copyright information in PMC

References

    1. Statement on sarcoidosis. Joint statement of the American thoracic society (ATS), the European respiratory society (ERS) and the world association of sarcoidosis and other granulomatous disorders (WASOG) adopted by the ATS board of directors and by the ERS executive committee, February 1999, Am. J. Respir. Crit. Care Med. 160 (1999) 736–755. - PubMed
    1. Bradley B, et al., Interstitial lung disease guideline: the British thoracic society in collaboration with the thoracic society of Australia and New Zealand and the Irish thoracic society, Thorax 63 (Suppl 5) (2008) v1–58. - PubMed
    1. Vorselaars ADM, et al., Methotrexate vs azathioprine in second-line therapy of sarcoidosis, Chest 144 (2013) 805–812. - PubMed
    1. Beegle SH, Barba K, Gobunsuy R, Judson MA, Current and emerging pharmacological treatments for sarcoidosis: a review, Drug Des. Dev. Ther. 7 (2013) 325–338. - PMC - PubMed
    1. Baughman RP, et al., Infliximab therapy in patients with chronic sarcoidosis and pulmonary involvement, Am. J. Respir. Crit. Care Med. 174 (2006) 795–802. - PubMed

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