Twists and turns to translating 4-1BB cancer immunotherapy

Miguel F Sanmamed^{1

2

3

4}, Iñaki Etxeberría¹, Itziar Otano¹, Ignacio Melero^{5

2

3

4}

Affiliations

¹ Centro de Investigación Médica Aplicada (CIMA), Pamplona, Spain.
² Clínica Universidad de Navarra, Pamplona, Spain.
³ Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
⁴ Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain.
⁵ Centro de Investigación Médica Aplicada (CIMA), Pamplona, Spain. imelero@unav.es.

Comment

Miguel F Sanmamed et al. Sci Transl Med. 2019.

. 2019 Jun 12;11(496):eaax4738.

doi: 10.1126/scitranslmed.aax4738.

Miguel F Sanmamed^{1

2

3

4}, Iñaki Etxeberría¹, Itziar Otano¹, Ignacio Melero^{5

2

3

4}

¹ Centro de Investigación Médica Aplicada (CIMA), Pamplona, Spain.
² Clínica Universidad de Navarra, Pamplona, Spain.
³ Centro de Investigación Biomédica en Red de Cáncer (CIBERONC), Madrid, Spain.
⁴ Navarra Institute for Health Research (IDISNA), 31008 Pamplona, Spain.
⁵ Centro de Investigación Médica Aplicada (CIMA), Pamplona, Spain. imelero@unav.es.

Abstract

Previous shortcomings of CD137-targeted immunotherapy may be overcome by engineered bispecific agents (Claus et al, this issue).

Tumor-targeted 4-1BB agonists for combination with T cell bispecific antibodies as off-the-shelf therapy.
Claus C, Ferrara C, Xu W, Sam J, Lang S, Uhlenbrock F, Albrecht R, Herter S, Schlenker R, Hüsser T, Diggelmann S, Challier J, Mössner E, Hosse RJ, Hofer T, Brünker P, Joseph C, Benz J, Ringler P, Stahlberg H, Lauer M, Perro M, Chen S, Küttel C, Bhavani Mohan PL, Nicolini V, Birk MC, Ongaro A, Prince C, Gianotti R, Dugan G, Whitlow CT, Solingapuram Sai KK, Caudell DL, Burgos-Rodriguez AG, Cline JM, Hettich M, Ceppi M, Giusti AM, Crameri F, Driessen W, Morcos PN, Freimoser-Grundschober A, Levitsky V, Amann M, Grau-Richards S, von Hirschheydt T, Tournaviti S, Mølhøj M, Fauti T, Heinzelmann-Schwarz V, Teichgräber V, Colombetti S, Bacac M, Zippelius A, Klein C, Umaña P. Claus C, et al. Sci Transl Med. 2019 Jun 12;11(496):eaav5989. doi: 10.1126/scitranslmed.aav5989. Sci Transl Med. 2019. PMID: 31189721 Free PMC article.