Adipose Tissue Composition in Obesity and After Bariatric Surgery

Gian Franco Adami^{1

2}, Federico Carbone^{3

4}, Fabrizio Montecucco^{3

4}, Giovanni Camerini^{3

4

5}, Renzo Cordera^{3

4}

Affiliations

¹ Department of Internal Medicine, University of Genova, 8, viale Benedetto XV, 16132, Genova, Italy. adami@unige.it.
² IRCCS, Azienda Ospedale-Universitaria San Martino, Genoa, Italy. adami@unige.it.
³ Department of Internal Medicine, University of Genova, 8, viale Benedetto XV, 16132, Genova, Italy.
⁴ IRCCS, Azienda Ospedale-Universitaria San Martino, Genoa, Italy.
⁵ Department of Surgery, University of Genova, Genoa, Italy.

PMID: 31190263
DOI: 10.1007/s11695-019-04030-z

Review

Adipose Tissue Composition in Obesity and After Bariatric Surgery

Gian Franco Adami et al. Obes Surg. 2019 Sep.

. 2019 Sep;29(9):3030-3038.

doi: 10.1007/s11695-019-04030-z.

Authors

Gian Franco Adami^{1

2}, Federico Carbone^{3

4}, Fabrizio Montecucco^{3

4}, Giovanni Camerini^{3

4

5}, Renzo Cordera^{3

4}

Affiliations

¹ Department of Internal Medicine, University of Genova, 8, viale Benedetto XV, 16132, Genova, Italy. adami@unige.it.
² IRCCS, Azienda Ospedale-Universitaria San Martino, Genoa, Italy. adami@unige.it.
³ Department of Internal Medicine, University of Genova, 8, viale Benedetto XV, 16132, Genova, Italy.
⁴ IRCCS, Azienda Ospedale-Universitaria San Martino, Genoa, Italy.
⁵ Department of Surgery, University of Genova, Genoa, Italy.

PMID: 31190263
DOI: 10.1007/s11695-019-04030-z

Abstract

The adipose tissue is a complex organ that regulates food intake and energy expenditure as well as induces low-grade inflammation. This review deals with changes in the composition and activity of the adipose organ after bariatric surgery, focusing on epicardial and ectopic fat and on relationships between white and brown adipose tissues. Postoperative improvements of ectopic fat and epicardial fat size and composition account for the metabolic recovery and the decreased cardiovascular risk. Following Roux-en-Y gastric bypass or biliopancreatic diversion, a proportional increase in the size and activity of the metabolically active brown adipose tissue was observed, most likely related to the postoperative rearrangement of the entero-hormonal pattern with an increase of GLP-1 production: this aspect would promote the postoperative weight loss and maintenance of post-surgery benefits.

Keywords: Bariatric surgery; Brown adipose tissue; Ectopic fat; Epicardial fat; Obesity.

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Adipose Tissue Composition in Obesity and After Bariatric Surgery

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Adipose Tissue Composition in Obesity and After Bariatric Surgery

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