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Comment
. 2019 Jul;97(6):523-525.
doi: 10.1111/imcb.12270. Epub 2019 Jun 12.

β-synuclein at the "synapse" of encephalitis and neurodegeneration in multiple sclerosis?

Sarah A Richman  1 , Christopher A Hunter  2
Affiliations
Comment

β-synuclein at the "synapse" of encephalitis and neurodegeneration in multiple sclerosis?

Sarah A Richman et al. Immunol Cell Biol. 2019 Jul.

Abstract

Lodygin and colleagues recently identified a candidate grey matter target antigen in a rat model of multiple sclerosis, a disease classically associated with the white matter antigen, myelin.

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  • β-Synuclein-reactive T cells induce autoimmune CNS grey matter degeneration.
    Lodygin D, Hermann M, Schweingruber N, Flügel-Koch C, Watanabe T, Schlosser C, Merlini A, Körner H, Chang HF, Fischer HJ, Reichardt HM, Zagrebelsky M, Mollenhauer B, Kügler S, Fitzner D, Frahm J, Stadelmann C, Haberl M, Odoardi F, Flügel A. Lodygin D, et al. Nature. 2019 Feb;566(7745):503-508. doi: 10.1038/s41586-019-0964-2. Epub 2019 Feb 20. Nature. 2019. PMID: 30787438

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