Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 May 8:12:1181-1197.
doi: 10.2147/IDR.S201324. eCollection 2019.

Prevalence of antibiotic resistance in Escherichia coli strains simultaneously isolated from humans, animals, food, and the environment: a systematic review and meta-analysis

Ali Pormohammad  1 , Mohammad Javad Nasiri  2 , Taher Azimi  2   3
Affiliations
Review

Prevalence of antibiotic resistance in Escherichia coli strains simultaneously isolated from humans, animals, food, and the environment: a systematic review and meta-analysis

Ali Pormohammad et al. Infect Drug Resist. .

Abstract

Background: Antimicrobial resistance is a serious public health problem worldwide. We aimed to investigate the prevalence of antibiotic resistance in Escherichia coli strains simultaneously isolated from humans, animals, food, and the environment. Methods: Studies on PubMed, Embase, and the Cochrane Library published from January 1, 2000 to January 1, 2018 were searched. The quality of the included studies was assessed by the modified critical appraisal checklist recommended by the Joanna Briggs Institute. All analyses were conducted using Biostat's Comprehensive Meta-Analysis version 2.0. Depending on the heterogeneity test for each antibiotic, we used a random- or fixed-effect model for pooled prevalence of drug resistance. Studies were eligible if they had investigated and reported resistance in two or more isolation sources (human, animal, food, or environment). To decrease heterogeneity and bias, we excluded studies that had reported E. coli drug resistance isolated from one source only. We included publications that reported drug resistance with minimum inhibitory concentration or disk diffusion method (DDM) as antibiotic-susceptibility tests. Results: Of the 39 included studies, 20 used the DDM and 19 minimum inhibitory concentration for their antibiotic-susceptibility testing. Colistin had the lowest prevalence, with 0.8% (95% CI 0.2%-3.8%) and amoxicillin the highest, with 70.5% (95% CI 57.5%-81%) in isolated human E. coli strains tested with the DDM. To assess historical changes in antimicrobial drug resistance, subgroup analysis from 2000 to 2018 showed a significant increase in ciprofloxacin resistance. Conclusion: Monitoring and evaluating antibiotic-sensitivity patterns and preparation of reliable antibiotic strategies may lead to better outcomes for inhibition and control of E. coli infections in different regions of the world.

Keywords: Escherichia coli; antibiotic; drug resistance.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Flow diagram of literature search and study selection.
Figure 2
Figure 2
Prevalence of antibiotic resistance in human, animal, food/environment E. coli isolates with disk diffusion method.
Figure 3
Figure 3
Prevalence of antibiotic resistance in human, animal, food/environment E. coli isolates with MIC method. Abbreviation: MIC, minimum inhibitory concentration.
Figure 4
Figure 4
The global prevalence of ciprofloxacin-resistant clinical (human) isolates with DDM and MIC method. Abbreviations: MIC, minimum inhibitory concentration; DDM, disc diffusion method.
Figure 5
Figure 5
The prevalence of ciprofloxacin-resistant clinical (human) isolates in WHO regional offices with MIC method.
Figure 6
Figure 6
Subgroup analyses of ciprofloxacin-resistant clinical (human) isolates with the MIC method from 2000–2018. Abbreviation: MIC, minimum inhibitory concentration.
See this image and copyright information in PMC

References

    1. Bryce A, Hay AD, Lane IF, Thornton HV, Wootton M, Costelloe C. Global prevalence of antibiotic resistance in paediatric urinary tract infections caused by Escherichia coli and association with routine use of antibiotics in primary care: systematic review and meta-analysis. BMJ. 2016;352:i939. doi:10.1136/bmj.i1717 - DOI - PMC - PubMed
    1. Bonnedahl J, Drobni P, Johansson A, et al. Characterization, and comparison, of human clinical and black-headed gull (Larus ridibundus) extended-spectrum β-lactamase-producing bacterial isolates from Kalmar, on the southeast coast of Sweden. J Antimicrob Chemother. 2010;65(9):1939–1944. doi:10.1093/jac/dkq222 - DOI - PubMed
    1. Bhoomika SS, Patyal A, Gade NE. Occurrence and characteristics of extended-spectrum β-lactamases producing Escherichia coli in foods of animal origin and human clinical samples in Chhattisgarh, India. Vet World. 2016;9(9):996. doi:10.14202/vetworld.2016.996-1000 - DOI - PMC - PubMed
    1. Yang C, Lin M, Liao P, et al. Comparison of antimicrobial resistance patterns between clinical and sewage isolates in a regional hospital in Taiwan. Lett Appl Microbiol. 2009;48(5):560–565. doi:10.1111/j.1472-765X.2009.02572.x - DOI - PubMed
    1. Boonyasiri A, Tangkoskul T, Seenama C, Saiyarin J, Tiengrim S, Thamlikitkul V. Prevalence of antibiotic resistant bacteria in healthy adults, foods, food animals, and the environment in selected areas in Thailand. Pathog Glob Health. 2014;108(5):235–245. doi:10.1179/2047773214Y.0000000148 - DOI - PMC - PubMed