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Review
. 2019 May 13:12:1243-1255.
doi: 10.2147/IDR.S175014. eCollection 2019.

Recent advances in Staphylococcus aureus infection: focus on vaccine development

Shamshul Ansari  1 , Rajesh Kumar Jha  2 , Shyam Kumar Mishra  3 , Birendra Raj Tiwari  4 , Ahmed Morad Asaad  5
Affiliations
Review

Recent advances in Staphylococcus aureus infection: focus on vaccine development

Shamshul Ansari et al. Infect Drug Resist. .

Abstract

Staphylococcus aureus normally colonizes the nasal cavity and pharynx. After breaching the normal habitat, the organism is able to cause a number of infections at any site of the body. The development of antibiotic resistance has created a global challenge for treating infections. Therefore, protection by vaccines may provide valuable measures. Currently, several vaccine candidates have been prepared which are either in preclinical phase or in early clinical phase, whereas several candidates have failed to show a protective efficacy in human subjects. Approaches have also been made in the development of monoclonal or polyclonal antibodies for passive immunization to protect from S. aureus infections. Therefore, in this review we have summarized the findings of recently published scientific literature to make a concise report.

Keywords: Staphylococcus aureus; active immunization; passive immunization; vaccine.

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Conflict of interest statement

The authors report no conflicts of interest in this work.

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