Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 May 14:12:685-702.
doi: 10.2147/DMSO.S201594. eCollection 2019.

Plasma cholinesterase is associated with Chinese adolescent overweight or obesity and metabolic syndrome prediction

Yanshuo Han  1   2 , Yanan Ma  1   3 , Yang Liu  1 , Zhongyi Zhao  1 , Shihan Zhen  1 , Xuelian Yang  1 , Zhiyong Xu  4 , Deliang Wen  1
Affiliations

Plasma cholinesterase is associated with Chinese adolescent overweight or obesity and metabolic syndrome prediction

Yanshuo Han et al. Diabetes Metab Syndr Obes. .

Abstract

Purpose: To determine the plasma concentrations of butyrylcholinesterase (BChE), also known as pseudocholinesterase, in different weight categories of adolescents, and to explore the possible association between plasma BChE and overweight (OW), obesity, and metabolic syndrome (MetS) in Chinese adolescents. Patients and methods: This cross-sectional study included 1,236 Chinese adolescents (194 obese [OB], 188 OW, 732 normal weight [NW], and 122 underweight [UW]). The biochemical variables and anthropometric variables of the study participants were evaluated. Plasma BChE level was measured by DGKC method. Results: OB was associated with a higher prevalence of upper strata plasma BChE levels when compared with the BChE levels in UW, NW, and OW group. A logistic regression analysis showed that plasma BChE was positively associated with the OB group when compared with the NW group. Boys in the OW group, but not the OB group, had a significantly higher prevalence of upper stratum of BChE levels. Plasma triglyceride, total cholesterol, low-density lipoprotein-cholesterol, and ApoB levels were positively associated with the upper stratum of BChE levels when compared with lower stratum. MetS and most of its components were more prevalent among subjects with upper stratum rather than lower stratum BChE levels. Receiver operating characteristic curves for plasma BChE in subjects with MetS indicated that the AUC was 0.80 (95%CI:0.70-0.90,P<0.001) and 0.89 (95%CI:0.82-0.95,P<0.001) in girls and boys, respectively. After adjusting for age, the multivariate-adjusted odds ratio for MetS in the upper stratum of BChE levels was 8.73 (95%CI: 3.49-21.84) in the boys cohorts and also in the girls cohorts (OR=1.71, 95%CI: 1.35-21.70). Conclusion: This study confirmed an association between BChE levels and weight status in Chinese adolescents, and demonstrated that the upper strata of plasma BChE levels were associated with being OW, and even more highly associated with obesity. Plasma BChE levels were positively associated with MetS and its components and could be useful for identifying adolescents with MetS.

Keywords: adolescents obesity; butyrylcholinesterase (BChE); dyslipidemia; metabolic syndrome.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
The northeast of Chinese adolescents participant flow.
Figure 2
Figure 2
Age-adjusted mean plasma BChE levels by the number of components of metabolic syndrome (error bars represent standard error of the mean). Black columns represent data for boys, and shaded columns represent data for girls.
Figure 3
Figure 3
Receiver operating characteristic curves of plasma BChE level for metabolic syndrome in girls and boys.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Pelone F, Specchia ML, Veneziano MA, et al. Economic impact of childhood obesity on health systems: a systematic review. Obes Rev. 2012;13(5):431–440. doi:10.1111/j.1467-789X.2011.00968.x - DOI - PubMed
    1. Wang Y, Beydoun MA, Liang L, Caballero B, Kumanyika SK. Will all Americans become overweight or obese? Estimating the progression and cost of the US obesity epidemic. Obesity (Silver Spring). 2008;16(10):2323–2330. doi:10.1038/oby.2008.351 - DOI - PubMed
    1. Nasreddine L, Naja F, Akl C, et al. Dietary, lifestyle and socio-economic correlates of overweight, obesity and central adiposity in Lebanese children and adolescents. Nutrients. 2014;6(3):1038–1062. doi:10.3390/nu6031038 - DOI - PMC - PubMed
    1. Koren D, Chirinos JA, Katz LE, et al. Interrelationships between obesity, obstructive sleep apnea syndrome and cardiovascular risk in obese adolescents. Int J Obes (Lond). 2015;39(7):1086–1093. doi:10.1038/ijo.2015.67 - DOI - PMC - PubMed
    1. Nicholas LM, Morrison JL, Rattanatray L, Zhang S, Ozanne SE, McMillen IC. The early origins of obesity and insulin resistance: timing, programming and mechanisms. Int J Obes (Lond). 2016;40(2):229–238. doi:10.1038/ijo.2015.178 - DOI - PubMed