Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 May 20:12:731-742.
doi: 10.2147/DMSO.S195859. eCollection 2019.

Immunogenetics of new onset diabetes after transplantation in Kuwait

Mohamed Jahromi  1 , Torki Al-Otaibi  2 , Nashwa Othman  3 , Osama Gheith  2 , Tarek Mahmoud  2 , Prasad Nair  2 , Medhat A Halim  2 , Narayanam Nampoory  1   2
Affiliations

Immunogenetics of new onset diabetes after transplantation in Kuwait

Mohamed Jahromi et al. Diabetes Metab Syndr Obes. .

Abstract

Introduction and aim: New onset diabetes after transplantation (NODAT) is a serious metabolic complication following kidney transplantation. Although beta-cell dysfunction is considered the main contributing factor in the development of this complication, its exact etiology is yet to be identified. We aimed to investigate NODAT among kidney transplant cohort in Kuwait with special stress on correlation between its risk factors and interferon gamma genotyping. Materials and methods: We surveyed 309 kidney transplant recipients from Hamed Al Essa Transplantation Centre, Kuwait. The participants were categorized into cohorts according to the development of NODAT diagnosed based on the American Diabetes Association guidelines. Statistical analyses were performed using SPSS software. We genotyped interferon gamma as the leading immunosignature for T lymphocyte. Results: No relationship between ethnicity and the development of NODAT was identified. However, there was a significant difference in age between cohorts. Younger patients demonstrated a lower rate of NODAT while, NODAT reached its maximum in 40-60-year age group. IFNG TT genotype was significantly associated with NODAT (p=0.005), while IFNG AA was considerably higher in the non-NODAT group. Conclusion: Beside the conventional contributing factors of NODAT, our results might represent a suitable platform for a larger cytokine and chemokine spectrum genotyping.

Keywords: NODAT; ethnicity; immunosuppression; transplantation.

PubMed Disclaimer

Conflict of interest statement

The authors report no conflicts of interest in this work.

Figures

Figure 1
Figure 1
Illustration of age specificity among study group. Notes: The trend among non-NODAT follows the age factor and patients’ physiology. The younger the age, the higher their tolerance towards the disease. NODAT reaches its extremities among middle age category, 40–60 years. Abbreviation: NODAT, new onset diabetes after transplantation.
See this image and copyright information in PMC

References

    1. Ghisdal L, Van Laecke S, Abramowicz MJ, Vanholder R, Abramowicz D. New-onset diabetes after renal transplantation: risk assessment and management. Diabetes Care. 2012;35(1):181–188. doi:10.2337/dc11-1230 - DOI - PMC - PubMed
    1. Davidson J, Wilkinson A, Dantal J, et al. New-onset diabetes after transplantation: 2003 International consensus guidelines. Proceedings of an international expert panel meeting. Barcelona, Spain, 19 February 2003. Transplantation. 2003;75(10Suppl):SS3–SS24. doi:10.1097/01.TP.0000069952.49242.3E - DOI - PubMed
    1. Chadban S. New-onset diabetes after transplantation – should it be a factor in choosing an immunosuppressant regimen for kidney transplant recipients? Nephrol Dial Transplant. 2008;23(6):1816–1818. doi:10.1093/ndt/gfn052 - DOI - PubMed
    1. Chadban S, Morris R, Hirsch HH, Bunnapradist S, Arns W, Budde K. Immunosuppression in renal transplantation: some aspects for the modern era. Transplant Rev. 2008;22(4):241–251. doi:10.1016/j.trre.2008.05.003 - DOI - PubMed
    1. Marcen R, Morales JM, Arias M, et al. Ischemic heart disease after renal transplantation in patients on cyclosporine in Spain. J Am Soc Nephrol. 2006;17(12 Suppl 3):S286–S290. doi:10.1681/ASN.2006080928 - DOI - PubMed