Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
. 2019 May 29:10:655.
doi: 10.3389/fphys.2019.00655. eCollection 2019.

Toll-Like Receptor 4 and Blood Pressure: Lessons From Animal Studies

Kenia Pedrosa Nunes  1 , Amanda Almeida de Oliveira  1 , Victor Vitorino Lima  2 , R Clinton Webb  3
Affiliations

Toll-Like Receptor 4 and Blood Pressure: Lessons From Animal Studies

Kenia Pedrosa Nunes et al. Front Physiol. .
No abstract available

Keywords: TLR4; animal models; blood pressure; hypertension; immune system.

PubMed Disclaimer

Figures

Figure 1
Figure 1
Toll-like receptor 4 and blood pressure in animal models of hypertension. In animal models where systemic TLR4 blockade lowers BP (DOCA-salt, Aldo-salt, and SHR) the improvement of the BBB counteracts the central RAAS system, which decreases the sympathetic tone. However, in AngII-infused animals, AngII reaches the brain through areas lacking the BBB and stimulates receptors in cells of the brain. Thus, sympathetic activation persists, and BP does not decrease. Central TLR4 blockade lowers BP in all studied animal models of hypertension. TLR4: Toll-like receptor 4; BP: blood pressure; SHR: spontaneously hypertensive rats; RAAS: renin-angiotensin-aldosterone system; AngII: angiotensin II.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Basting T., Lazartigues E. (2017). DOCA-salt hypertension: an update. Curr. Hypertens. Rep. 19:32. 10.1007/s11906-017-0731-4 - DOI - PMC - PubMed
    1. Beuschlein F. (2010). Animal models of primary aldosteronism. Horm. Metab. Res. 42, 446–449. 10.1055/s-0029-1243205 - DOI - PubMed
    1. Biancardi V. C., Bomfim G. F., Reis W. L., Al-Gassimi S., Nunes K. P. (2017). The interplay between angiotensin II, TLR4 and hypertension. Pharmacol. Res. 120, 88–96. 10.1016/j.phrs.2017.03.017 - DOI - PubMed
    1. Biancardi V. C., Son S. J., Ahmadi S., Filosa J. A., Stern J. E. (2014). Circulating angiotensin II gains access to the hypothalamus and brain stem during hypertension via breakdown of the blood-brain barrier. Hypertension 63, 572–579. 10.1161/HYPERTENSIONAHA.113.01743 - DOI - PMC - PubMed
    1. Biancardi V. C., Stern J. E. (2016). Compromised blood–brain barrier permeability: novel mechanism by which circulating angiotensin II signals to sympathoexcitatory centres during hypertension. J. Physiol. 594, 1591–1600. 10.1113/JP271584 - DOI - PMC - PubMed

LinkOut - more resources