Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jan 30:18:e20180021.
doi: 10.1590/1677-5449.002118. eCollection 2019.

What has changed in venous thromboembolism prophylaxis for hospitalized patients over recent decades: review article

Selma Regina de Oliveira Raymundo  1   2 , Suzana Margareth Ajeje Lobo  1 , Kassim Mohamede Kassim Hussain  1 , Kassim Guzzon Hussein  3 , Isabela Tobal Secches  3
Affiliations
Review

What has changed in venous thromboembolism prophylaxis for hospitalized patients over recent decades: review article

Selma Regina de Oliveira Raymundo et al. J Vasc Bras. .

Abstract
in English, Portuguese

Venous thromboembolism (VTE) is a common disease with high rates of morbidity and mortality and is considered the number one cause of avoidable mortality among hospitalized patients. Although VTE incidence is extremely high in all countries and there is ample evidence that thromboprophylaxis inexpensively reduces the rate of thromboembolic complications in both clinical and surgical patients, a great deal of doubt remains with respect to patient safety with this type of intervention and in relation to the ideal thromboprophylaxis methods. Countless studies and evidence-based recommendations confirm the efficacy of prophylaxis for prevention of VTE and/or patient deaths, but it remains underutilized to this day. This article presents a wide-ranging review of existing prophylaxis methods up to the present, from guidelines and national and international studies of thromboprophylaxis.

Resumo: O tromboembolismo venoso (TEV) é uma doença frequente e de alta morbimortalidade, sendo considerada a maior causa evitável de mortalidade em pacientes hospitalizados. Apesar da incidência altíssima de TEV em todos os países e das evidências de que a tromboprofilaxia reduz as complicações tromboembólicas em pacientes clínicos e cirúrgicos, e a custo baixo, persistem grandes dúvidas quanto à segurança desse tipo de intervenção nos pacientes e quanto à tromboprofilaxia ideal. Inúmeros estudos e recomendações baseadas em evidências comprovam a eficácia da profilaxia na prevenção do TEV e/ou da morte dos pacientes, mas ainda hoje ela é subutilizada. Neste artigo, apresentamos uma ampla revisão dos métodos de profilaxia existentes até os dias atuais, publicados em diretrizes e estudos nacionais e internacionais sobre tromboprofilaxia.

Keywords: anticoagulants; prevention & control; venous thromboembolism.

PubMed Disclaimer

Conflict of interest statement

Conflicts of interest: No conflicts of interest declared concerning the publication of this article.

Similar articles

See all similar articles

Cited by

References

    1. MacDougall DA, Feliu AL, Boccuzzi SJ, Lin J. Economic burden of deep vein thrombosis, pulmonary embolism, and post-thrombotic syndrome. Am J Health Syst Pharm. 2006;63(20) Suppl 6:S5–15. doi: 10.2146/ajhp060388. - DOI - PubMed
    1. Geerts WH, Bergqvist D, Pineo GF, et al. revention of venous thromboembolism: American College of Chest Physicians Evidence-Based Clinical Practice Guidelines (8th Edition) Chest. 2008;133(6 Suppl):381S–453S. - PubMed
    1. Beckman MG, Hooper WC, Critchley SE, Ortel TL. Venous thromboembolism: a public health concern. Am J Prev Med. 2010;38(4) Suppl:S495–501. doi: 10.1016/j.amepre.2009.12.017. - DOI - PubMed
    1. Heit JA. The epidemiology of venous thromboembolism in the community: implications for prevention and management. J Thromb. 2006;21(1):23–29. doi: 10.1007/s11239-006-5572-y. - DOI - PubMed
    1. Spyropoulos AC, Hussein M, Lin J, Battleman D. Rates of symptomatic venous thromboembolism in US surgical patients: a retrospective administrative database study. J Thromb Thrombolysis. 2009;28(4):458–464. doi: 10.1007/s11239-009-0351-1. - DOI - PubMed

LinkOut - more resources