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Review
. 2019 May 2:2019:1607304.
doi: 10.1155/2019/1607304. eCollection 2019.

Triclosan: An Update on Biochemical and Molecular Mechanisms

Affiliations
Review

Triclosan: An Update on Biochemical and Molecular Mechanisms

Mohammad A Alfhili et al. Oxid Med Cell Longev. .

Abstract

Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in commercial and healthcare products. Items made with TCS include soaps, deodorants, shampoos, cosmetics, textiles, plastics, surgical sutures, and prosthetics. A wealth of information obtained from in vitro and in vivo studies has demonstrated the therapeutic effects of TCS, particularly against inflammatory skin conditions. Nevertheless, extensive investigations on the molecular aspects of TCS action have identified numerous adversaries associated with the disinfectant including oxidative injury and influence of physiological lifespan and longevity. This review presents a summary of the biochemical alterations pertaining to TCS exposure, with special emphasis on the diverse molecular pathways responsive to TCS that have been elucidated during the present decade.

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