Triclosan: An Update on Biochemical and Molecular Mechanisms
- PMID: 31191794
- PMCID: PMC6525925
- DOI: 10.1155/2019/1607304
Triclosan: An Update on Biochemical and Molecular Mechanisms
Abstract
Triclosan (TCS) is a synthetic, chlorinated phenolic antimicrobial agent commonly used in commercial and healthcare products. Items made with TCS include soaps, deodorants, shampoos, cosmetics, textiles, plastics, surgical sutures, and prosthetics. A wealth of information obtained from in vitro and in vivo studies has demonstrated the therapeutic effects of TCS, particularly against inflammatory skin conditions. Nevertheless, extensive investigations on the molecular aspects of TCS action have identified numerous adversaries associated with the disinfectant including oxidative injury and influence of physiological lifespan and longevity. This review presents a summary of the biochemical alterations pertaining to TCS exposure, with special emphasis on the diverse molecular pathways responsive to TCS that have been elucidated during the present decade.
Similar articles
-
Phenotypically anchored transcriptome profiling of developmental exposure to the antimicrobial agent, triclosan, reveals hepatotoxicity in embryonic zebrafish.Toxicol Appl Pharmacol. 2016 Oct 1;308:32-45. doi: 10.1016/j.taap.2016.08.013. Epub 2016 Aug 15. Toxicol Appl Pharmacol. 2016. PMID: 27538710 Free PMC article.
-
Is Triclosan a neurotoxic agent?J Toxicol Environ Health B Crit Rev. 2017;20(2):104-117. doi: 10.1080/10937404.2017.1281181. Epub 2017 Feb 22. J Toxicol Environ Health B Crit Rev. 2017. PMID: 28339349 Review.
-
Triclosan (TCS) and Triclocarban (TCC) cause lifespan reduction and reproductive impairment through oxidative stress-mediated expression of the defensome in the monogonont rotifer (Brachionus koreanus).Comp Biochem Physiol C Toxicol Pharmacol. 2016 Jul-Aug;185-186:131-137. doi: 10.1016/j.cbpc.2016.04.002. Epub 2016 Apr 9. Comp Biochem Physiol C Toxicol Pharmacol. 2016. PMID: 27067728
-
The commonly used antimicrobial additive triclosan is a liver tumor promoter.Proc Natl Acad Sci U S A. 2014 Dec 2;111(48):17200-5. doi: 10.1073/pnas.1419119111. Epub 2014 Nov 17. Proc Natl Acad Sci U S A. 2014. PMID: 25404284 Free PMC article.
-
Triclosan: A Widespread Environmental Toxicant with Many Biological Effects.Annu Rev Pharmacol Toxicol. 2016;56:251-72. doi: 10.1146/annurev-pharmtox-010715-103417. Annu Rev Pharmacol Toxicol. 2016. PMID: 26738475 Free PMC article. Review.
Cited by
-
Recent Advances in the Control of Clinically Important Biofilms.Int J Mol Sci. 2022 Aug 23;23(17):9526. doi: 10.3390/ijms23179526. Int J Mol Sci. 2022. PMID: 36076921 Free PMC article. Review.
-
Adverse effects of triclosan exposure on health and potential molecular mechanisms.Sci Total Environ. 2023 Jun 25;879:163068. doi: 10.1016/j.scitotenv.2023.163068. Epub 2023 Mar 23. Sci Total Environ. 2023. PMID: 36965724 Free PMC article. Review.
-
A Short Review of the Toxicity of Dentifrices-Zebrafish Model as a Useful Tool in Ecotoxicological Studies.Int J Mol Sci. 2023 Sep 20;24(18):14339. doi: 10.3390/ijms241814339. Int J Mol Sci. 2023. PMID: 37762640 Free PMC article. Review.
-
Development of a GIS-based knowledge hub for contaminants of emerging concern in South African water resources using open-source software: Lessons learnt.Heliyon. 2023 Jan 18;9(1):e13007. doi: 10.1016/j.heliyon.2023.e13007. eCollection 2023 Jan. Heliyon. 2023. PMID: 36747952 Free PMC article.
-
PPARγ Regulates Triclosan Induced Placental Dysfunction.Cells. 2021 Dec 28;11(1):86. doi: 10.3390/cells11010086. Cells. 2021. PMID: 35011648 Free PMC article.
References
-
- Kjaerheim V., Skaare A., Barkvoll P., Rolla G. Antiplaque, antibacterial, and anti-inflammatory properties of triclosan mouthrinses in combination with zinc citrate or polyvinylmethylether maleic acid (PVM-MA) copolymer. European Journal of Oral Sciences. 1996;104(5-6):529–534. doi: 10.1111/j.1600-0722.1996.tb00137.x. - DOI - PubMed
-
- Kjaerheim V., Waaler S. M., Rolla G. Organic solvents and oils as vehicles for triclosan in mouthrinses: a clinical study. Scandinavian Journal of Dental Research. 1994;102(5):306–308. - PubMed
-
- Kjaerheim V., Waaler S. M., Rolla G. Significance of choice of solvents for the clinical effect of triclosan-containing mouthrinses. Scandinavian Journal of Dental Research. 1994;102(4):202–205. - PubMed
Publication types
MeSH terms
Substances
Grants and funding
LinkOut - more resources
Full Text Sources