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Review
. 2019 May 22:9:408.
doi: 10.3389/fonc.2019.00408. eCollection 2019.

Limitations and Opportunities in Open Laryngeal Organ Preservation Surgery: Current Role of OPHLs

Giovanni Succo  1   2 , Erika Crosetti  2
Affiliations
Review

Limitations and Opportunities in Open Laryngeal Organ Preservation Surgery: Current Role of OPHLs

Giovanni Succo et al. Front Oncol. .

Abstract

The current trend for treatment of intermediate-early advanced laryngeal cancer is essentially oriented toward preservation of organ and laryngeal function, and with a good potential for treating the disease. This goal can be achieved by adopting open laryngeal organ preservation surgery (OLOPS), at present mainly represented by open partial horizontal laryngectomies (OPHLs). An approach using rigorous selection criteria based on both the general condition of the patient and the local and regional extent of the disease gives excellent oncological and functional results in untreated patients. Similar outcomes, albeit slightly worse, are also obtainable in radio-recurrent and laser-recurrent patients. Troublesome postoperative management and the inconsistency of functional recovery are the main limitations for extensive application of this therapeutic strategy. The future direction is represented by simplification of the indications identifying iso-prognostic sub-categories within the T-stage, wider consensus on rehabilitation protocols, hybrid approaches to the larynx, and open minimally invasive access.

Keywords: functional results; laryngeal cancer; outcome; partial laryngectomy; quality of life; salvage surgery; supracricoid laryngectomy; supratracheal laryngectomy.

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References

    1. The Department of Veterans Affairs Laryngeal Cancer Study Group. Wolf GT, Fisher SG, Hong WK, Hillman R, Spaulding M, Laramore GE, et al. . Induction chemotherapy plus radiation compared with surgery plus radiation in patients with advanced laryngeal cancer. N Engl J Med. (1991) 324:1685–90. 10.1056/NEJM199106133242402 - DOI - PubMed
    1. Forastiere AA, Goepfert H, Maor M, Maor M, Pajak TF, Weber R, et al. . Concurrent chemotherapy and radiotherapy for organ preservation in advanced laryngeal cancer. N Engl J Med. (2003) 349:2091–8. 10.1056/NEJMoa031317 - DOI - PubMed
    1. Forastiere AA, Zhang Q, Weber RS, Maor MH, Goepfert H, Pajak TF, et al. . Long-term results of RTOG 91–11: a comparison of three nonsurgical treatment strategies to preserve the larynx in patients with locally advanced larynx cancer. J Clin Oncol. (2013) 31:845–52. 10.1200/JCO.2012.43.6097 - DOI - PMC - PubMed
    1. Thomas L, Drinnan M, Natesh B, Mehanna H, Jones T, Paleri V. Open conservation partial laryngectomy for laryngeal cancer: a systematic review of English language literature. Cancer Treat Rev. (2012) 38:203–11. 10.1016/j.ctrv.2011.05.010 - DOI - PubMed
    1. Peretti G, Piazza C, Cocco D, De Benedetto L, Del Bon F, Redaelli De Zinis LO, et al. . Transoral CO(2) laser treatment for T(is)-T(3) glottic cancer: the University of Brescia experience on 595 patients. Head Neck. (2010) 32:977–83. 10.1002/hed.21278 - DOI - PubMed