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. 2019 Aug;100(8):1200-1201.
doi: 10.1099/jgv.0.001280. Epub 2019 Jun 13.

ICTV Virus Taxonomy Profile: Arenaviridae

Affiliations

ICTV Virus Taxonomy Profile: Arenaviridae

Sheli R Radoshitzky et al. J Gen Virol. 2019 Aug.

Abstract

Members of the family Arenaviridae produce enveloped virions containing genomes consisting of two or three single-stranded RNA segments totalling about 10.5 kb. Arenaviruses can infect mammals, including humans and other primates, snakes, and fish. This is a summary of the International Committee on Taxonomy of Viruses (ICTV) Report on the family Arenaviridae, which is available at www.ictv.global/report/arenaviridae.

Keywords: Arenaviridae; ICTV Report; arenavirus; mammarenavirus; reptarenavirus; taxonomy.

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Conflict of interest statement

Conflicts of interest: The authors declare that there are no conflicts of interest.

Figures

Fig. 1.
Fig. 1.
(a) Electron micrograph of lymphocytic choriomeningitis virus particles, showing dark internal inclusion bodies, budding from an infected cell. (b) Schematic illustration of a (mammalian) arenavirus particle. Shown is the spherical and enveloped (grey) particle that is spiked with glycoproteins (GP, gold) around a layer of zinc finger matrix proteins (Z, brown; missing in hartmaniviruses). The small and large ribonucleoprotein (RNP) complexes inside the particle consist of nucleoprotein (NP, blue) and RNA-dependent RNA polymerase (L, green).
Fig. 2.
Fig. 2.
Schematic representation of the bisegmented genome organization of the mammalian arenavirus lymphocytic choriomeningitis virus. The 5′- and 3′-ends of both segments (S and L) are complementary at their termini, probably promoting the formation of circular RNP complexes within the virion. GPC, glycoprotein precursor; L, RNA-dependent RNA polymerase; NP, nucleoprotein; Z, zinc finger matrix protein. ORFs are separated by non-coding IGRs with predicted hairpin structures (not shown).

References

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