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Meta-Analysis
. 2019 Jun;98(24):e15876.
doi: 10.1097/MD.0000000000015876.

Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis

Cong Lu  1 , Long Zhou  1 , Jing Ouyang  2 , Huajing Yang  2
Affiliations
Meta-Analysis

Prognostic value of lymphocyte-to-monocyte ratio in ovarian cancer: A meta-analysis

Cong Lu et al. Medicine (Baltimore). 2019 Jun.

Abstract

Background: Lymphocyte-to-monocyte ratio (LMR) was recently proposed as a prognostic factor of ovarian cancer. However, prognostic value of the LMR in ovarian cancer remains inconclusive. The study aimed to assess prognostic value of the LMR in ovarian cancer.

Methods: Seven common databases were comprehensively searched for relevant studies. The analyses were performed for overall survival (OS), progression-free survival (PFS) and clinical parameters. The hazard ratio (HR) and 95% confidence interval (CI) were used to analyze OS and PFS.

Results: A total of 2343 patients with ovarian cancer were included in this meta-analysis. The results showed that a low LMR predicted shorter OS (HR = 1.81, 95% CI = 1.38-2.37, P < .01) and PFS (HR = 1.65 95% CI = 1.46-1.85, P < .01) when compared to a high LMR in ovarian cancer. Besides, a low LMR was significantly associated with advanced clinical stage (P < .01), earlier lymph node metastasis (P = .01), higher carbohydrate antigen-125 levels (P < .01), larger residual tumor (P < .01) and worse chemosensitivity (P < .01) when compared to a high LMR in ovarian cancer.

Conclusion: Low LMR was associated with unfavorable survival in patients with ovarian cancer. LMR could serve as a prognostic biomarker of ovarian cancer.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Figure 1
Figure 1
The flow chart of literature search and selection.
Figure 2
Figure 2
The meta-analysis for association between the LMR and OS (a, forest plot; b, sensitivity analysis; c, funnel plot). LMR = lymphocyte-to-monocyte ratio, OS = overall survival.
Figure 3
Figure 3
The meta-analysis for association between the LMR and PFS (a, forest plot; b, funnel plot). LMR = lymphocyte-to-monocyte ratio, PFS = progression-free survival.
Figure 4
Figure 4
The funnel plots for association between the LMR and clinical parameters (a, age; b, histology; c, histologic grade; d, FIGO stage; e, lymph node metastasis; f, CA-125; g, residual tumor; h, chemosensitivity). CA-125 = carbohydrate antigen-125, FIGO = International Federation of Gynecology and Obstetrics, LMR = lymphocyte-to-monocyte ratio.
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