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. 2019 May 13;5(5):e01715.
doi: 10.1016/j.heliyon.2019.e01715. eCollection 2019 May.

Positive correlation between fasting plasma glucagon and serum C-peptide in Japanese patients with diabetes

Yoshiya Hosokawa  1 , Junji Kozawa  1 , Hitoshi Nishizawa  1 , Dan Kawamori  1   2 , Norikazu Maeda  1   3 , Michio Otsuki  1 , Taka-Aki Matsuoka  1 , Hiromi Iwahashi  1   4 , Iichiro Shimomura  1
Affiliations

Positive correlation between fasting plasma glucagon and serum C-peptide in Japanese patients with diabetes

Yoshiya Hosokawa et al. Heliyon. .

Abstract

Aims: Glucagon plays pivotal roles in systemic glucose homeostasis mainly by promoting hepatic glucose output. Using a sandwich enzyme-linked immunosorbent assay (ELISA), we evaluated fasting plasma glucagon levels in hospitalized patients with type 1 or type 2 diabetes, and assessed the relationships between glucagon levels and various clinical parameters.

Methods: We enrolled adult Japanese diabetes patients admitted to Osaka University Medical Hospital for glycemic control between July 2017 and May 2018 in this study. After patients had fasted for 12 h, blood samples were obtained and plasma glucagon levels were measured using a sandwich ELISA.

Results: Total 107 patients participated in the study. The mean fasting plasma glucagon level of patients with acute onset type 1 diabetes was significantly lower than that of patients with type 2 diabetes (p < 0.05). Plasma glucagon levels were not significantly correlated with plasma glucose levels in patients with type 1 diabetes or in patients with type 2 diabetes. Multiple regression analysis indicated that fasting glucagon levels were independently and significantly correlated with fasting serum C-peptide levels in patients with type 2 diabetes.

Conclusions: Our results suggest that insulin and glucagon secretion are balanced in the fasting state in patients with type 2 diabetes.

Keywords: Metabolism.

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Figures

Fig. 1
Fig. 1
Simple linear regression analyses between fasting glucose and glucagon levels in patients with type 1 diabetes and type 2 diabetes.
Fig. 2
Fig. 2
Simple linear regression analyses between fasting glucose and glucagon levels in patients with type 2 diabetes dividing into under treatment with or without DPP-4 inhibitor or GLP-1 analog.
Fig. 3
Fig. 3
Simple linear regression analyses between fasting C-peptide and glucagon levels in patients with type 2 diabetes.
Fig. 4
Fig. 4
Simple linear regression analyses between fasting C-peptide and glucagon levels in patients with type 2 diabetes dividing into under treatment with or without insulin (a) and into under treatment with or without DPP-4 inhibitor or GLP-1 analog (b).
See this image and copyright information in PMC

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References

    1. Ramnanan C.J., Edgerton D.S., Kraft G., Cherrington A.D. Physiologic action of glucagon on liver glucose metabolism. Diabetes Obes. Metab. 2011;13:118–125. - PMC - PubMed
    1. Unger R.H., Cherrington A.D. Glucagonocentric restructuring of diabetes: a pathophysiologic and therapeutic makeover. J. Clin. Investig. 2012;122:4–12. https://www.jci.org/articles/view/60016 - PMC - PubMed
    1. Knop F.K., Aaboe K., Vilsbøll T., Vølund A., Holst J.J., Krarup T., Madsbad S. Impaired incretin effect and fasting hyperglucagonaemia characterizing type 2 diabetic subjects are early signs of dysmetabolism in obesity. Diabetes Obes. Metab. 2012;14:500–510. - PubMed
    1. Müller W.A., Faloona G.R., Aguilar-Parada E., Unger R.H. Abnormal alpha-cell function in diabetes. Response to carbohydrate and protein ingestion. N. Engl. J. Med. 1970;283:109–115. - PubMed
    1. Kawai K., Murayama Y., Okuda Y., Yamashita K. Postprandial glucose, insulin and glucagon responses to meals with different nutrient compositions in non-insulin-dependent diabetes mellitus. Endocrinol. Jpn. 1987;34:745–753. https://www.jstage.jst.go.jp/article/endocrj1954/34/5/34_5_745/_article - PubMed

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