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Review
. 2019 Apr 10:30:100549.
doi: 10.1016/j.nmni.2019.100549. eCollection 2019 Jul.

adeABC efflux gene in Acinetobacter baumannii

C Xu  1 , S R Bilya  1 , W Xu  1
Affiliations
Review

adeABC efflux gene in Acinetobacter baumannii

C Xu et al. New Microbes New Infect. .

Abstract

The antimicrobial resistance to Acinetobacter baumannii is significantly high and continues to grow; it has become a global health issue, particularly in regards to carbapenem resistance. The expression of efflux pumps is one of the major mechanisms of antibiotic resistance in A. baumannii by, most prevalently, adeABC of the resistance/nodulation/division family. The detection rate of adeB was the highest in clinical isolates compared to others (adeFGH, adeIJk), although it varied among other strains. In this minireview, we explain the adeABC efflux gene in A. baumannii causing antibiotic resistance and compare adeABC with other efflux genes in order to discern the function of adeABC in A. baumannii resistance, which may help in the discovery of new antibacterial agents.

Keywords: Acinetobacter baumannii; adeABC efflux gene; antibiotic resistance; efflux pumps; infection.

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Figures

Fig. 1
Fig. 1
Function of adeABC efflux pump in cell wall of Acinetobacter baumannii. adeA acts as membrane fusion protein, adeB as multidrug transporter and adeC as outer membrane protein. adeB captures antibiotics in inner membrane of phospholipids bilayer or cytoplasm, then transports substrates out by adeC (membrane channel protein).
See this image and copyright information in PMC

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