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Review
. 2019 Feb 21;4(2):63-68.
doi: 10.1016/j.ncrna.2019.02.002. eCollection 2019 Jun.

Dietary non-coding RNAs from plants: Fairy tale or treasure?

Gopinath M Sundaram  1   2
Affiliations
Review

Dietary non-coding RNAs from plants: Fairy tale or treasure?

Gopinath M Sundaram. Noncoding RNA Res. .

Erratum in

Abstract

The past two decades have witnessed soaring interest in the field of non-coding RNAs, largely attributed by its regulatory role in controlling two third of human transcriptional output. Though, there are several classes of non-coding RNAs found in nature, microRNAs takes the central stage because of their pleiotropic roles. In particular, extracellular microRNAs are gaining traction due to their relative stability and bio availability. Extracellular microRNAs has been shown to occur in all living organisms, including dietary plants. Some of the recent reports suggest that these dietary microRNAs pass through the gut, enter systemic circulation and exert biological effects on animal physiology. However, evidences against this hypothesis are also presented in literature and hence this area has been strongly debated. In this review, I will briefly summarise the evidences accumulated for and against this hypothesis and discuss potential implications of such findings in human health.

Keywords: Dietary non-coding RNAs; microRNAs and edible nanoparticles.

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Figures

Fig. 1
Fig. 1
Comparison of miRNA biogenesis in animals and plants.
See this image and copyright information in PMC

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