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. 2019 May 15:24:103992.
doi: 10.1016/j.dib.2019.103992. eCollection 2019 Jun.

Data set of in silico simulation for the production of clavulanic acid and cephamycin C by Streptomyces clavuligerus using a genome scale metabolic model

Stephania Gómez-Cerón  1 , David Galindo-Betancur  1 , Howard Ramírez-Malule  1
Affiliations

Data set of in silico simulation for the production of clavulanic acid and cephamycin C by Streptomyces clavuligerus using a genome scale metabolic model

Stephania Gómez-Cerón et al. Data Brief. .

Abstract

Streptomyces clavuligerus (S. clavuligerus) is a Gram-positive bacterium which produced clavulanic acid (CA) and cephamycin C (CephC). In this data article, a curated genome scale metabolic model of S. clavuligerus is presented. A total of eighteen objective functions were evaluated for a better representation of CA and CephC production by S. clavuligerus. The different objective functions were evaluated varying the weighting factors of CA and CephC between 0, 1 y 2, whereas for the case of biomass the weight factor was varied between 1 and 2. A robustness analysis, by mean of flux balance analysis, showed five different metabolic phenotypes of S. clavuligerus as a function of oxygen uptake: (I) and (II) biomass production, (III) biomass and CephC production, (IV) simultaneous production of biomass, CA and CephC and (V) production of biomass and CA. Data of shadow prices and reduced cost are also presented.

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Figures

Fig. 1
Fig. 1
Profile of biomass, CA and CephC while varying oxygen uptake for the objective function No. 6.
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