Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Case Reports
. 2019 Jun 3;5(6):501-503.
doi: 10.1016/j.jdcr.2019.03.017. eCollection 2019 Jun.

Topiramate-induced reactive granulomatous dermatitis

Sara Mater  1 , Jonathan J Lee  2 , Jaroslaw Jedrych  2 , Misha Rosenbach  3 , Joseph C English 3rd  2
Affiliations
Case Reports

Topiramate-induced reactive granulomatous dermatitis

Sara Mater et al. JAAD Case Rep. .
No abstract available

Keywords: GA, granuloma annulare; RGD, reactive granulomatous dermatitis; diRGD, drug-induced reactive granulomatous dermatitis; drug-induced reactive granulomatous dermatitis; granuloma annulare; granulomatous dermatitis; reactive granulomatous dermatitis; topiramate.

PubMed Disclaimer

Figures

Fig 1
Fig 1
Clinical findings at presentation. Pink papules coalescing into linear serpiginous cords and expansile annular plaques with central clearing.
Fig 2
Fig 2
Histologic findings (low power). Scanning magnification shows a palisaded and interstitial lymphohistiocytic infiltrate in the dermis. (Original magnification: ×5.)
Fig 3
Fig 3
Histologic findings (high power). Higher power highlights a palisade of histiocytes and multinucleated giant cells surrounding a focus of necrobiosis. (Original magnification: ×40.)
Fig 4
Fig 4
Clinical findings after discontinuation of topiramate. Four months after discontinuation of topiramate, the patient experienced near-complete resolution of dermatologic findings.
See this image and copyright information in PMC

References

    1. Rosenbach M., English J.C., 3rd Reactive granulomatous dermatitis: a review of palisaded neutrophilic and granulomatous dermatitis, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, and a proposed reclassification. Dermatol Clin. 2015;33(3):373–387. - PubMed
    2. Rosenbach M, English JC, 3rd. Reactive granulomatous dermatitis: a review of palisaded neutrophilic and granulomatous dermatitis, interstitial granulomatous dermatitis, interstitial granulomatous drug reaction, and a proposed reclassification. Dermatol Clin 2015;33(3):373-387. - PubMed
    1. Friedman B.E., English J.C., 3rd Drug-induced sarcoidosis in a patient treated with an interleukin-1 receptor antagonist for hidradenitis suppurativa. JAAD Case Rep. 2018;4(6):543–545. - PMC - PubMed
    2. Friedman BE, English JC, 3rd. Drug-induced sarcoidosis in a patient treated with an interleukin-1 receptor antagonist for hidradenitis suppurativa. JAAD Case Rep 2018;4(6):543-545. - PMC - PubMed
    1. Jenkinson H.A., Siroy A.E., Choksi A. Granuloma annulare secondary to vemurafenib therapy for lung adenocarcinoma. J Drugs Dermatol. 2017;16(10):1050–1052. - PubMed
    2. Jenkinson HA, Siroy AE, Choksi A. Granuloma annulare secondary to vemurafenib therapy for lung adenocarcinoma. J Drugs Dermatol 2017;16(10):1050-1052. - PubMed
    1. Ruzzetti M., Saraceno R., Peris K., Chimenti S. Is there an association between topiramate and granuloma annulare? J Eur Acad Dermatol Venereol. 2010;24(2):238–239. - PubMed
    2. Ruzzetti M, Saraceno R, Peris K, Chimenti S. Is there an association between topiramate and granuloma annulare? J Eur Acad Dermatol Venereol 2010;24(2):238-239. - PubMed
    1. Cassone G., Tumiati B. Granuloma annulare as a possible new adverse effect of topiramate. Int J Dermatol. 2014;53(2):259–261. - PubMed
    2. Cassone G, Tumiati B. Granuloma annulare as a possible new adverse effect of topiramate. Int J Dermatol 2014;53(2):259-261. - PubMed

Publication types

LinkOut - more resources