Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Book

Hypertonic Fluids

Alexi Mason  1 , Ahmad Malik  2 , Jacob G. Ginglen  3
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
.
Affiliations
Free Books & Documents
Book

Hypertonic Fluids

Alexi Mason et al.
Free Books & Documents

Excerpt

Clinicians use hypertonic fluids to increase intravascular fluid volume. Hypertonic saline can be utilized in the treatment of hyponatremia. Hypertonic saline and mannitol are both indicated to reduce intracranial pressure. This activity will highlight the mechanism of action, adverse events, and contraindications of hypertonic fluids in the management of hyponatremia and increased intracranial pressure.

PubMed Disclaimer

Conflict of interest statement

Disclosure: Alexi Mason declares no relevant financial relationships with ineligible companies.

Disclosure: Ahmad Malik declares no relevant financial relationships with ineligible companies.

Disclosure: Jacob Ginglen declares no relevant financial relationships with ineligible companies.

References

    1. Williams DM, Gallagher M, Handley J, Stephens JW. The clinical management of hyponatraemia. Postgrad Med J. 2016 Jul;92(1089):407-11. - PubMed
    1. Sokhal N, Rath GP, Chaturvedi A, Singh M, Dash HH. Comparison of 20% mannitol and 3% hypertonic saline on intracranial pressure and systemic hemodynamics. J Clin Neurosci. 2017 Aug;42:148-154. - PubMed
    1. Oddo M, Levine JM, Frangos S, Carrera E, Maloney-Wilensky E, Pascual JL, Kofke WA, Mayer SA, LeRoux PD. Effect of mannitol and hypertonic saline on cerebral oxygenation in patients with severe traumatic brain injury and refractory intracranial hypertension. J Neurol Neurosurg Psychiatry. 2009 Aug;80(8):916-20. - PubMed
    1. Witherspoon B, Ashby NE. The Use of Mannitol and Hypertonic Saline Therapies in Patients with Elevated Intracranial Pressure: A Review of the Evidence. Nurs Clin North Am. 2017 Jun;52(2):249-260. - PubMed
    1. Pfortmueller CA, Schefold JC. Hypertonic saline in critical illness - A systematic review. J Crit Care. 2017 Dec;42:168-177. - PubMed

Publication types

LinkOut - more resources