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Book

Doxepin

Anasheh Almasi  1 , Preeti Patel, Carlos E. Meza  2
In: StatPearls [Internet]. Treasure Island (FL): StatPearls Publishing; 2025 Jan.
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Affiliations
Book

Doxepin

Anasheh Almasi et al.

Excerpt

Doxepin belongs to the class of tricyclic antidepressant medications approved by the US Food and Drug Administration (FDA) for the treatment of major depressive disorder, anxiety, and insomnia, as well as for managing skin pruritus. Doxepin functions by increasing the concentration of the neurotransmitter serotonin (5-hydroxytryptamine or 5-HT) and norepinephrine (NE) in the brain. This mechanism extends the availability of the neurotransmitters (5-HT and NE) within the synaptic cleft and enhances their neurotransmission by preventing their reuptake into the presynaptic terminal.

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Conflict of interest statement

Disclosure: Anasheh Almasi declares no relevant financial relationships with ineligible companies.

Disclosure: Preeti Patel declares no relevant financial relationships with ineligible companies.

Disclosure: Carlos Meza declares no relevant financial relationships with ineligible companies.

References

    1. Owen RT. Selective histamine H(1) antagonism: a novel approach to insomnia using low-dose doxepin. Drugs Today (Barc) 2009 Apr;45(4):261-7. - PubMed
    1. Wu J, Chang F, Zu H. Efficacy and safety evaluation of citalopram and doxepin on sleep quality in comorbid insomnia and anxiety disorders. Exp Ther Med. 2015 Oct;10(4):1303-1308. - PMC - PubMed
    1. Kouwenhoven TA, van de Kerkhof PCM, Kamsteeg M. Use of oral antidepressants in patients with chronic pruritus: A systematic review. J Am Acad Dermatol. 2017 Dec;77(6):1068-1073.e7. - PubMed
    1. Eschler DC, Klein PA. An evidence-based review of the efficacy of topical antihistamines in the relief of pruritus. J Drugs Dermatol. 2010 Aug;9(8):992-7. - PubMed
    1. Ju T, Vander Does A, Mohsin N, Yosipovitch G. Lichen Simplex Chronicus Itch: An Update. Acta Derm Venereol. 2022 Oct 19;102:adv00796. - PMC - PubMed

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