A Tale of Two Mutations: Beginning to Understand the Problems with Egg-Based Influenza Vaccines?

Kanta Subbarao¹, Ian Barr²

Affiliations

¹ The WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. Electronic address: kanta.subbarao@influenzacentre.org.
² The WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

PMID: 31194938
DOI: 10.1016/j.chom.2019.05.012

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A Tale of Two Mutations: Beginning to Understand the Problems with Egg-Based Influenza Vaccines?

Kanta Subbarao et al. Cell Host Microbe. 2019.

Free article

. 2019 Jun 12;25(6):773-775.

doi: 10.1016/j.chom.2019.05.012.

Authors

Kanta Subbarao¹, Ian Barr²

Affiliations

¹ The WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia. Electronic address: kanta.subbarao@influenzacentre.org.
² The WHO Collaborating Centre for Reference and Research on Influenza, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia; Department of Microbiology and Immunology, The University of Melbourne, The Peter Doherty Institute for Infection and Immunity, Melbourne, VIC, Australia.

PMID: 31194938
DOI: 10.1016/j.chom.2019.05.012

Abstract

The majority of influenza vaccines are produced in embryonated eggs, but mutations occur as human influenza A(H3N2) viruses adapt to grow in eggs. This can alter virus antigenicity. Wu et al. (2019) reveal that there are two mutually exclusive pathways for egg adaptation, which has potential implications for future egg-based influenza vaccines.

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Preventing an Antigenically Disruptive Mutation in Egg-Based H3N2 Seasonal Influenza Vaccines by Mutational Incompatibility.
Wu NC, Lv H, Thompson AJ, Wu DC, Ng WWS, Kadam RU, Lin CW, Nycholat CM, McBride R, Liang W, Paulson JC, Mok CKP, Wilson IA. Wu NC, et al. Cell Host Microbe. 2019 Jun 12;25(6):836-844.e5. doi: 10.1016/j.chom.2019.04.013. Epub 2019 May 28. Cell Host Microbe. 2019. PMID: 31151913 Free PMC article.

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A Tale of Two Mutations: Beginning to Understand the Problems with Egg-Based Influenza Vaccines?

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A Tale of Two Mutations: Beginning to Understand the Problems with Egg-Based Influenza Vaccines?

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