Dysbiosis and Prematurity: Is There a Role for Probiotics?

doi:10.3390/nu11061273

Review

. 2019 Jun 5;11(6):1273.

doi: 10.3390/nu11061273.

Dysbiosis and Prematurity: Is There a Role for Probiotics?

Maria Elisabetta Baldassarre¹, Antonio Di Mauro², Manuela Capozza³, Valentina Rizzo⁴, Federico Schettini⁵, Raffaella Panza⁶, Nicola Laforgia⁷

Affiliations

¹ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. mariaelisabetta.baldassarre@uniba.it.
² Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. antonio.dimauro@uniba.it.
³ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. manuela.capozza@uniba.it.
⁴ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. rizzo.vale.vr@gmail.com.
⁵ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. federico.schettini@virgilio.it.
⁶ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. raffaella.panza@uniba.it.
⁷ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. nicola.laforgia@uniba.it.

PMID: 31195600
PMCID: PMC6627287
DOI: 10.3390/nu11061273

Review

Dysbiosis and Prematurity: Is There a Role for Probiotics?

Maria Elisabetta Baldassarre et al. Nutrients. 2019.

. 2019 Jun 5;11(6):1273.

doi: 10.3390/nu11061273.

Authors

Maria Elisabetta Baldassarre¹, Antonio Di Mauro², Manuela Capozza³, Valentina Rizzo⁴, Federico Schettini⁵, Raffaella Panza⁶, Nicola Laforgia⁷

Affiliations

¹ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. mariaelisabetta.baldassarre@uniba.it.
² Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. antonio.dimauro@uniba.it.
³ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. manuela.capozza@uniba.it.
⁴ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. rizzo.vale.vr@gmail.com.
⁵ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. federico.schettini@virgilio.it.
⁶ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. raffaella.panza@uniba.it.
⁷ Neonatology and Neonatal Intensive Care Unit, Department of Biomedical Science and Human Oncology, "Aldo Moro" University of Bari, P.zza Giulio Cesare 11, 70124 Bari, Italy. nicola.laforgia@uniba.it.

PMID: 31195600
PMCID: PMC6627287
DOI: 10.3390/nu11061273

Abstract

Healthy microbiota is a critical mediator in maintaining health and it is supposed that dysbiosis could have a role in the pathogenesis of a number of diseases. Evidence supports the hypothesis that maternal dysbiosis could act as a trigger for preterm birth; aberrant colonization of preterm infant gut might have a role in feeding intolerance and pathogenesis of necrotizing enterocolitis. Despite several clinical trials and meta-analyses, it is still not clear if modulation of maternal and neonatal microbiota with probiotic supplementation decreases the risk of preterm birth and its complications.

Keywords: Premature” [MeSH]; “Dysbiosis” [MeSH]; “Infant; “Premature Birth” [MeSH]; “Probiotics” [MeSH].

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Conflict of interest statement

The authors declare no conflict of interest.

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References

1. Petersen C., Round J.L. Defining dysbiosis and its influence on host immunity and disease. Cell. Microbiol. 2014;16:1024–1033. doi: 10.1111/cmi.12308. - DOI - PMC - PubMed
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[1] Petersen C., Round J.L. Defining dysbiosis and its influence on host immunity and disease. Cell. Microbiol. 2014;16:1024–1033. doi: 10.1111/cmi.12308. - DOI - PMC - PubMed

[2] Petersen C., Round J.L. Defining dysbiosis and its influence on host immunity and disease. Cell. Microbiol. 2014;16:1024–1033. doi: 10.1111/cmi.12308. - DOI - PMC - PubMed

[3] Liu L., Oza S., Hogan D., Perin J., Rudan I., Lawn J.E., Cousens S., Mathers C., Black R.E. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015;385:430–440. doi: 10.1016/S0140-6736(14)61698-6. - DOI - PubMed

[4] Liu L., Oza S., Hogan D., Perin J., Rudan I., Lawn J.E., Cousens S., Mathers C., Black R.E. Global, regional, and national causes of child mortality in 2000–13, with projections to inform post-2015 priorities: an updated systematic analysis. Lancet. 2015;385:430–440. doi: 10.1016/S0140-6736(14)61698-6. - DOI - PubMed

[5] Romero R., Dey S.K., Fisher S.J. Preterm labor: one syndrome, many causes. Science. 2014;345:760–765. doi: 10.1126/science.1251816. - DOI - PMC - PubMed

[6] Romero R., Dey S.K., Fisher S.J. Preterm labor: one syndrome, many causes. Science. 2014;345:760–765. doi: 10.1126/science.1251816. - DOI - PMC - PubMed

[7] Peaceman A.M., Lai Y., Rouse D.J., Spong C.Y., Mercer B.M., Varner M.W., Thorp J.M., Ramin S.M., Malone F.D., O’sullivan M.J., et al. Length of latency with preterm premature rupture of membranes before 32 weeks’ gestation. Am. J. Perinatol. 2015;32:57–62. - PMC - PubMed

[8] Peaceman A.M., Lai Y., Rouse D.J., Spong C.Y., Mercer B.M., Varner M.W., Thorp J.M., Ramin S.M., Malone F.D., O’sullivan M.J., et al. Length of latency with preterm premature rupture of membranes before 32 weeks’ gestation. Am. J. Perinatol. 2015;32:57–62. - PMC - PubMed

[9] Mattison D.R., Damus K., Fiore E., Petrini J., Alter C. Preterm delivery: A public health perspective. Paediatr. Perinat. Epidemiol. 2001;15(Suppl. 2):7–16. doi: 10.1046/j.1365-3016.2001.00004.x. - DOI - PubMed

[10] Mattison D.R., Damus K., Fiore E., Petrini J., Alter C. Preterm delivery: A public health perspective. Paediatr. Perinat. Epidemiol. 2001;15(Suppl. 2):7–16. doi: 10.1046/j.1365-3016.2001.00004.x. - DOI - PubMed

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Dysbiosis and Prematurity: Is There a Role for Probiotics?

Affiliations

Dysbiosis and Prematurity: Is There a Role for Probiotics?

Authors

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Abstract

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