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Review
. 2019 Jun 5;20(11):2757.
doi: 10.3390/ijms20112757.

The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia-Review

Weronika Dymara-Konopka  1 , Marzena Laskowska  2
Affiliations
Review

The Role of Nitric Oxide, ADMA, and Homocysteine in The Etiopathogenesis of Preeclampsia-Review

Weronika Dymara-Konopka et al. Int J Mol Sci. .

Abstract

Preeclampsia is a serious, pregnancy-specific, multi-organ disease process of compound aetiology. It affects 3-6% of expecting mothers worldwide and it persists as a leading cause of maternal and foetal morbidity and mortality. In fact, hallmark features of preeclampsia (PE) result from vessel involvement and demonstrate maternal endothelium as a target tissue. Growing evidence suggests that chronic placental hypoperfusion triggers the production and release of certain agents that are responsible for endothelial activation and injury. In this review, we will present the latest findings on the role of nitric oxide, asymmetric dimethylarginine (ADMA), and homocysteine in the etiopathogenesis of preeclampsia and their possible clinical implications.

Keywords: asymmetric dimethylarginine; homocysteine; nitric oxide; preeclampsia.

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Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Physiological roles of NO pathway in pregnancy and their possible influence on preeclampsia (PE) development in two-stage model of disease. NO PATHWAY ROLE: Nitric oxide (NO) pathway role; STAGES OF PE: Stages of preeclampsia (PE).
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