Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Meta-Analysis
. 2019 Jun 5;55(6):247.
doi: 10.3390/medicina55060247.

Association between the FAS/FASL Variants and Risk of Male Infertility in Asian Populations; A Systematic Review and Meta-Analysis

Rezvan Asgari  1 , Kamran Mansouri  2 , Mitra Bakhtiari  3 , Hadi Mozafari  4 , Shiva Roshankhah  5
Affiliations
Meta-Analysis

Association between the FAS/FASL Variants and Risk of Male Infertility in Asian Populations; A Systematic Review and Meta-Analysis

Rezvan Asgari et al. Medicina (Kaunas). .

Abstract

Background and Objectives: Studies suggest that FAS/FASL polymorphisms are associated with male infertility; however, their results are still inconclusive. Therefore, this systematic review and meta-analysis aimed to summarize and clarify the overall association of FAS/FASL polymorphisms and risk of male infertility. Materials and Methods: Our search was conducted on the databases of Science Direct, PubMed and Google Scholar. For performing the meta-analysis, pooled odds ratio (OR) values with 95% confidence interval (CI) was applied in order to analyze the strength of association between the FAS/FASL polymorphisms and risk of male infertility. A total of seven relevant studies published up to September 2018 were considered. Results: FASL-844C/T genotype results of 559 patients and 623 healthy individuals were included in our study. For FAS-670A/G genotype effect, 751 patients and 821 healthy individuals were explored. Results showed that all analysis models including dominant, recessive and allelic models of FASL-844C/T and FAS-670A/G polymorphism had no significant effect on infertility in men (p > 0.05 and p > 0.05, respectively). According to sensitivity analysis, our results were stable. Conclusion: We demonstrated that FAS/FASL polymorphisms might not be an effective factor on male reproductive health. For precise determination of FAS/FASL polymorphisms effects on male infertility, large-scale case-control studies should be performed.

Keywords: FAS; FASL; male infertility; meta-analysis; polymorphism.

PubMed Disclaimer

Conflict of interest statement

The authors declare no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram of the search and study selection process according to inclusion and exclusion criteria. FASL: FAS Ligand.
Figure 2
Figure 2
Forest plots of odds ratios for the association between FASL-844C/T and male infertility in models of dominant, recessive and allelic ((A–C) for models of dominant, recessive and allelic, respectively).
Figure 3
Figure 3
Forest plots of odds ratios for the association between FAS-670A/G and male infertility in models of dominant, recessive and allelic ((A–C) for models of dominant, recessive and allelic, respectively).
Figure 4
Figure 4
Bias of literature for FASL-844C/T and FAS-670A/G was tested by Begg’s funnel plot and Egger’s test results are depicted for three different analysis models of FAS-670A/G (A): dominant; (B): recessive; (C): allelic and FASL-844C/T (D): dominant; (E): recessive; (F): allelic.
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

References

    1. Thoma M.E., McLain A.C., Louis J.F., King R.B., Trumble A.C., Sundaram R., Louis G.M.B. Prevalence of infertility in the United States as estimated by the current duration approach and a traditional constructed approach. Fertil. Steril. 2013;99:1324–1331. doi: 10.1016/j.fertnstert.2012.11.037. - DOI - PMC - PubMed
    1. Najafpour A., Aghaz F., Roshankhah S., Bakhtiari M. The effect of air dust pollution on semen quality and sperm parameters among infertile men in west of Iran. Aging Male. 2018:1–7. doi: 10.1080/13685538.2018.1482533. - DOI - PubMed
    1. Chen H., Fok K.L., Yu S., Jiang J., Chen Z., Gui Y., Cai Z., Chan H.C. CD147 is required for matrix metalloproteinases-2 production and germ cell migration during spermatogenesis. Mol. Hum. Reprod. 2011;17:405–414. doi: 10.1093/molehr/gar013. - DOI - PubMed
    1. Asgari R., Mansouri K., Bakhtiari M., Vaisi-Raygani A. CD147 as an apoptosis regulator in spermatogenesis: Deciphering its association with matrix metalloproteinases’ pathway. Mol. Biol. Rep. 2019;2:1–7. doi: 10.1007/s11033-018-4568-y. - DOI - PubMed
    1. Roshankhah S., Mansouri K., Bakhtiari M., Salahshoor M.R., Asgari R. Synergistic effects of TIMP2-418G/C and MMP9-1562C/T variants on the male infertility risk. Mol. Biol. Rep. 2018;4:1–6. doi: 10.1007/s11033-018-4541-9. - DOI - PubMed