Regulation of the metR gene of Salmonella typhimurium
- PMID: 3119572
- PMCID: PMC214181
- DOI: 10.1128/jb.169.12.5841-5844.1987
Regulation of the metR gene of Salmonella typhimurium
Abstract
Regulation of the Salmonella typhimurium metR gene was studied by measuring beta-galactosidase levels in Escherichia coli strains lysogenic for a lambda bacteriophage carrying a metR-lacZ fusion. The results indicate that the metR gene is negatively regulated by its own gene product and that this autoregulation involves homocysteine as a corepressor. In addition, the results indicate that the metR gene is negatively regulated by the metJ gene product over a 70- to 80-fold range.
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