Red Jujube-Incorporated Gelatin Methacryloyl (GelMA) Hydrogels with Anti-Oxidation and Immunoregulation Activity for Wound Healing

Abstract

Red jujube has a long history of consumption for its excellent antioxidant activity and immunoregulation. In this study, red jujube-incorporated gelatin-methacryloyl (GelMA) hydrogels were developed using a programmed mixing method for wound healing. A series of evaluations, including structural characterization, antioxidant activity in vitro and in vivo, immunoregulation, and wound healing effects, were conducted. The results indicated that the introduction of red jujube equipped the GelMA hydrogel with antioxidation ability and light immune-stimulation. The wound healing results further confirmed that red jujube hybrid hydrogel could be a promising wound dressing material.