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Review
. 2019 Nov;43(6):638-645.
doi: 10.1016/j.clinre.2019.04.005. Epub 2019 Jun 10.

Non-Alcoholic Fatty Liver Disease in Non-Obese Individuals: Prevalence, Pathogenesis and Treatment

Emilio Molina-Molina  1 , Marcin Krawczyk  2 , Ewa Stachowska  3 , Frank Lammert  4 , Piero Portincasa  5
Affiliations
Review

Non-Alcoholic Fatty Liver Disease in Non-Obese Individuals: Prevalence, Pathogenesis and Treatment

Emilio Molina-Molina et al. Clin Res Hepatol Gastroenterol. 2019 Nov.

Abstract

Non-alcoholic fatty liver disease (NAFLD) parallels comorbidities such as metabolic syndrome, dyslipidaemia or diabetes. Although NAFLD is very prevalent in overweight-obese individuals (i.e. body mass index ≥25 kg/m2), recent studies point to the presence of NAFLD in non-obese individuals, for both the Asian (<25 kg/m2) and Caucasian (<30 kg/m2) populations. This paper discusses the pathogenic pathways and current treatment options of NAFLD in non-obese populations. In this respect, non-obese subjects also need to undergo the medical screening for NAFLD. Across the scientific community, we aim to promote the advancement of knowledge in this emerging field.

Keywords: Body weight; Fat; Genetics; NAFLD.

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