How immunoglobulin V kappa genes rearrange
- PMID: 3119721
How immunoglobulin V kappa genes rearrange
Abstract
Recombination at the immunoglobulin kappa light chain locus creates a complete variable region gene and its reciprocal product. The results presented here show that reciprocal products may be substrates for secondary recombination and that at least one V kappa group rearranges by inversion.
Similar articles
-
Structure of a germline rabbit immunoglobulin V kappa-region gene: implications for rabbit V kappa-J kappa recombination.J Immunol. 1984 Nov;133(5):2753-6. J Immunol. 1984. PMID: 6434636
-
Structure of rearranged and germ-line rabbit V kappa genes indicated that the CDR3 is encoded by the V kappa gene.Eur J Immunol. 1990 Feb;20(2):259-64. doi: 10.1002/eji.1830200205. Eur J Immunol. 1990. PMID: 2107083
-
Limited junctional diversity in kappa light chains. Junctional sequences from CD43+B220+ early B cell progenitors resemble those from peripheral B cells.J Immunol. 1994 Apr 1;152(7):3467-75. J Immunol. 1994. PMID: 7511648
-
The variable genes of the human immunoglobulin kappa locus.Biol Chem Hoppe Seyler. 1993 Nov;374(11):1001-22. Biol Chem Hoppe Seyler. 1993. PMID: 8292259 Review. No abstract available.
-
Immunoglobulin genes.Annu Rev Immunol. 1983;1:499-528. doi: 10.1146/annurev.iy.01.040183.002435. Annu Rev Immunol. 1983. PMID: 6443559 Review. No abstract available.
Cited by
-
Immature surface Ig+ B cells can continue to rearrange kappa and lambda L chain gene loci.J Exp Med. 1993 Oct 1;178(4):1263-70. doi: 10.1084/jem.178.4.1263. J Exp Med. 1993. PMID: 8376934 Free PMC article.
-
Restricted kappa chain expression in early ontogeny: biased utilization of V kappa exons and preferential V kappa-J kappa recombinations.J Exp Med. 1993 May 1;177(5):1317-30. doi: 10.1084/jem.177.5.1317. J Exp Med. 1993. PMID: 8478611 Free PMC article.
-
Feedback inhibition of immunoglobulin gene rearrangement by membrane mu, but not by secreted mu heavy chains.J Exp Med. 1988 Oct 1;168(4):1363-81. doi: 10.1084/jem.168.4.1363. J Exp Med. 1988. PMID: 3139821 Free PMC article.
-
Direct evidence for intrastrand DNA inversion of kappa immunoglobulin gene segments in two murine plasmacytomas.Nucleic Acids Res. 1989 Dec 11;17(23):9797-809. doi: 10.1093/nar/17.23.9797. Nucleic Acids Res. 1989. PMID: 2513557 Free PMC article.
-
The regulated expression of B lineage associated genes during B cell differentiation in bone marrow and fetal liver.J Exp Med. 1993 Sep 1;178(3):951-60. doi: 10.1084/jem.178.3.951. J Exp Med. 1993. PMID: 8350062 Free PMC article.
Publication types
MeSH terms
Substances
Associated data
- Actions
- Actions
- Actions
- Actions