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. 2020 Apr 30;9(2):257-260.
doi: 10.1093/jpids/piz035.

Does Rotavirus Vaccination Affect Longer-Term Intussusception Risk in US Infants?

Rachel M Burke  1   2 , Jacqueline E Tate  1 , Rebecca M Dahl  3 , Negar Aliabadi  1 , Umesh D Parashar  1
Affiliations

Does Rotavirus Vaccination Affect Longer-Term Intussusception Risk in US Infants?

Rachel M Burke et al. J Pediatric Infect Dis Soc. .

Abstract

Rotavirus vaccination has been associated with a short-term increased risk of intussusception. Our analysis of insurance claims for 1 858 827 US children with 544 recorded cases of intussusception found a nonsignificant decrease in intussusception (hazard ratio, 0.79 [95% confidence interval, 0.57-1.09]) in fully rotavirus-vaccinated children followed up to the age of 2 years.

Keywords: immunizations; intussusception; pediatric gastroenteritis; rotavirus; rotavirus vaccine.

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Conflict of interest statement

CONFLICT OF INTEREST

No authors have any conflicts of interest to declare.

Figures

Figure 1:
Figure 1:. Unadjusted intussusception hospitalization survival curves.
A) Crude survival curve. The plot is shown beginning at 8 weeks and going to 2 years of age. Only children with at least 8 weeks of continuous enrollment were included (N = 1,858,827). B) Crude survival curve, by vaccination status. Intussusception survival curves overlapped among children fully vaccinated (green), as compared to children partially (yellow) or unvaccinated (red) against rotavirus. The plot is shown beginning at 27 weeks (N = 1,463,313), by which time all children are eligible to be fully vaccinated against rotavirus. Rotavirus vaccination status is treated as time-varying.
See this image and copyright information in PMC

References

    1. Murphy TV, Gargiullo PM, Massoudi MS, et al. Intussusception among infants given an oral rotavirus vaccine. N Engl J Med 2001; 344(8): 564–72. - PubMed
    1. Cortese MM, Parashar UD, CDC. Prevention of rotavirus gastroenteritis among infants and children: recommendations of the Advisory Committee on Immunization Practices (ACIP). MMWR Recomm Rep 2009; 58(RR-2): 1–25. - PubMed
    1. Ruiz-Palacios GM, Perez-Schael I, Velazquez FR, et al. Safety and efficacy of an attenuated vaccine against severe rotavirus gastroenteritis. N Engl J Med 2006; 354(1): 11–22. - PubMed
    1. Vesikari T, Matson DO, Dennehy P, et al. Safety and efficacy of a pentavalent human-bovine (WC3) reassortant rotavirus vaccine. N Engl J Med 2006; 354(1): 23–33. - PubMed
    1. Kassim P, Eslick GD. Risk of intussusception following rotavirus vaccination: An evidence based meta-analysis of cohort and case-control studies. Vaccine 2017; 35(33): 4276–86. - PubMed

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