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. 2019 Aug;145(8):2039-2044.
doi: 10.1007/s00432-019-02955-7. Epub 2019 Jun 13.

Aberrant expression of Sec61α in esophageal cancers

Kai Bachmann  1 , Maximillian Bockhorn  1 , Oliver Mann  1 , Florian Gebauer  1 , Marco Blessmann  2 , Jakob Robert Izbicki  1 , Katharina Grupp  3   4
Affiliations

Aberrant expression of Sec61α in esophageal cancers

Kai Bachmann et al. J Cancer Res Clin Oncol. 2019 Aug.

Abstract

Introduction: The heterotrimeric Sec61α translocon complex is topological located in the membrane of the endoplasmic reticulum (ER) and allows protein transport and calcium across the membrane. Recently, aberrant expression of Sec proteins was linked to carcinogenesis and prognosis of patients.

Materials and methods: Here, we analysed the role of Sec61α in esophageal cancer, and we analysed Sec61α staining on a tissue microarray containing more than 600 esophageal cancer specimens by immunohistochemistry.

Results: Sec61α staining was always strong in benign esophagus, but was only found in 5% of interpretable esophageal adenocarcinomas (EACs) and 14.5% of squamous cell carcinomas (ESCCs). Reduced Sec61α staining was not strongly linked to tumor phenotype in both subgroups of esophageal cancers and was unrelated to clinical outcome of patients (EACs: p = 0.8051 and ESCCs: p = 0.2751).

Conclusions: Thus, Sec61α measurement has not an additional prognostic benefit for the patients.

Keywords: Esophageal cancer; Sec61α; Tissue microarray.

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Conflict of interest statement

The authors declare that they have no conflict of interest.

Figures

Fig. 1
Fig. 1
Sec61α immunostaining in esophageal cancers. Negative and strong expression of Sec61α in EACs (a, b) and ESCCs (c, d)
Fig. 2
Fig. 2
Prognostic impact of Sec61α immunostaining in esophageal cancers. Relationship of Sec61α staining intensity with overall survival in EACs (n = 261; p = 0.8051; a) and ESCCs (n = 200; p = 0.2751; b)
See this image and copyright information in PMC

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