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. 2019 Mar;485(1):30-32.
doi: 10.1134/S0012496619020042. Epub 2019 Jun 13.

Physical Fatigue and Morphofunctional State of the Myocardium in Experimental Chronic Stress

M V Kondashevskaya  1 , V E Tseylikman  2 , M V Komelkova  2 , M S Lapshin  2 , A P Sarapultsev  3   4 , S S Lazuko  5 , O P Kuzhel  5 , E B Manukhina  2   6   7 , H F Downey  2   7 , M V Chereshneva  3 , V A Chereshnev  3   4
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Physical Fatigue and Morphofunctional State of the Myocardium in Experimental Chronic Stress

M V Kondashevskaya et al. Dokl Biol Sci. 2019 Mar.

Abstract

The relationship between the development of skeletal muscle fatigue of a specific type in male Wistar rats and morphofunctional alterations in the myocardium in the posttraumatic stress disorder (PTSD) model has been investigated for the first time. The aggravation of oxidative stress in the cardiomyocytes and the related transformation of the cell structural components and the depletion of energy reserves in PTSD has been identified as one of the main factors that accelerate the onset of musculoskeletal fatigue.

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