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Review
. 1987:24:191-6.

Neurofibrillary tangles and the neuronal cytoskeleton

B H Anderton  1 , J P Brion, J Flament-Durand, M C Haugh, J Kahn, C C Miller, A Probst, J Ulrich
Affiliations
  • PMID: 3119774
Review

Neurofibrillary tangles and the neuronal cytoskeleton

B H Anderton et al. J Neural Transm Suppl. 1987.

Abstract

Antibodies to neurofilaments and the microtubule-associated protein, tau, have been used with anti-paired helical filament (PHF) serum to study Alzheimer neurofibrillary tangles. Tangles and their constituent PHF contain epitopes derived from or cross-reactive with both neurofilaments and tau proteins. These same structures are labelled with anti-PHF antibodies. A component of the anti-PHF serum is against tau proteins. We conclude that PHF are at least in part derived from an abnormal neuronal cytoskeleton.

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