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Meta-Analysis
. 2019 Aug;8(9):4135-4148.
doi: 10.1002/cam4.2281. Epub 2019 Jun 13.

Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for breast cancer patients: An updated meta-analysis of 17079 individuals

Wanying Guo  1 , Xin Lu  2 , Qipeng Liu  1 , Ting Zhang  1 , Peng Li  1 , Weiqiang Qiao  1 , Miao Deng  1
Affiliations
Meta-Analysis

Prognostic value of neutrophil-to-lymphocyte ratio and platelet-to-lymphocyte ratio for breast cancer patients: An updated meta-analysis of 17079 individuals

Wanying Guo et al. Cancer Med. 2019 Aug.

Abstract

Aims: This study aimed to evaluate the prognostic effect of neutrophil-to-lymphocyte ratio (NLR) and platelet-to-lymphocyte ratio (PLR) for patients with breast cancer (BC).

Methods: A literature search was performed by searching medical databases. Basic characteristics and prognostic data were extracted from included studies. Primary outcomes, such as overall survival (OS) and disease-free survival (DFS), were synthesized and compared. Subgroup analyses were performed according to pathology, geographical region, cut-off value, and tumor progression.

Results: A total of 39 studies comprising 17079 BC patients were included in this meta-analysis. Among them, 28 studies with 142 64 BC patients investigated predicting role of NLR for OS, showing elevated NLR were associated poor prognosis (hazard ratio [HR]: 1.78, 95% confidence interval [CI]: 1.49-2.13, P < 0.001). Twenty-seven studies containing 115 04 patients explored the role of NLR in predicting DFS, showing elevated NLR was associated with poor DFS with HR of 1.60 (95% CI: 1.42-1.96, P < 0.001). Twelve studies explored the role of PLR in predicting OS, showing patients with higher PLR were associated with a significantly worse prognosis with a pooled HR of 1.32 (95% CI: 1.11-1.57, P = 0.002). Eleven studies with 5013 patients shown patients with elevated PLR were associated shorter DFS (HR: 1.43, 95% CI: 1.09-1.86, P = 0.009). Subgroup analyses shown a greater magnitude of association between NLR and OS in triple-negative BC patients than in HER2-positive ones.

Conclusions: Our study suggested that elevated NLR and PLR were associated with poor OS as well as high risk of recurrence for BC patients. Subgroup analyses confirmed the prognostic effect of NLR and PLR in HER2-positive BC patients. As easily accessible parameters, NLR and PLR should be identified as useful biomarkers in the management of BC.

Keywords: breast cancer; meta-analysis; neutrophil-to-lymphocyte ratio; platelet-to-lymphocyte ratio; prognosis.

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Conflict of interest statement

The authors declare that there are no conflict of interest.

Figures

Figure 1
Figure 1
Flow diagram showing study retrieval and selection process.
Figure 2
Figure 2
Forest plot of NLR in predicting OS (a) and DFS (b) of BC patients.
Figure 3
Figure 3
Forest plot of PLR in predicting OS (a) and DFS (b) of BC patients.
Figure 4
Figure 4
Sensitivity analyses and funnel plots of OS and DFS for NLR (a, b and e, f) and PLR (c, d and g, h).
See this image and copyright information in PMC

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