Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Jun 15;33(6):750-755.
doi: 10.7507/1002-1892.201901116.

[Research progress on controlled release of various growth factors in bone regeneration]

[Article in Chinese]
Lin Ji  1 , Ziwei Song  2 , Fuhai Zeng  1 , Ming Hu  2 , Siqi Chen  1 , Zhongjie Qin  2 , Delin Xia  3
Affiliations
Review

[Research progress on controlled release of various growth factors in bone regeneration]

[Article in Chinese]
Lin Ji et al. Zhongguo Xiu Fu Chong Jian Wai Ke Za Zhi. .

Abstract
in English, Chinese

Objective: To summarize the research progress of controlled release of angiogenic factors and osteogenic factors in bone tissue engineering.

Methods: The domestic and abroad literature on the controlled release structure of growth factors during bone regeneration in recent years was extensively reviewed and summarized.

Results: The sustained-release structure includes direct binding, microsphere-three-dimensional scaffold structure, core-shell structure, layer self-assembly, hydrogel, and gene carrier. A sustained-release system composed of different sustained-release structures combined with different growth factors can promote bone regeneration and angiogenesis.

Conclusion: Due to its controllability and persistence, the growth factor sustained-release system has become a research hotspot in bone tissue engineering and has broad application prospects.

目的: 总结近年来成血管因子和成骨因子在骨组织工程缓释系统中的研究进展。.

方法: 广泛查阅近年来国内外关于骨再生过程中生长因子缓释系统的研究报道，并加以分析总结。.

结果: 缓释结构包括直接结合、微球-三维支架结构、核-壳结构、层层自组装、水凝胶及基因载体等。不同缓释结构与不同生长因子结合构成的缓释系统能促进骨再生及新生血管形成。.

结论: 生长因子缓释系统因具有可控性和持续性等特点，已成为骨组织工程的研究热点，具有广泛应用前景。.

Keywords: Growth factor; angiogenesis; bone regeneration; controlled release.

PubMed Disclaimer

Similar articles

See all similar articles

Cited by

References

    1. Farokhi M, Mottaghitalab F, Shokrgozar MA, et al Importance of dual delivery systems for bone tissue engineering. J Control Release. 2016;225:152–169. doi: 10.1016/j.jconrel.2016.01.033. - DOI - PubMed
    1. Bayer EA, Gottardi R, Fedorchak MV, et al The scope and sequence of growth factor delivery for vascularized bone tissue regeneration. J Control Release. 2015;219:129–140. doi: 10.1016/j.jconrel.2015.08.004. - DOI - PubMed
    1. Larsen M, Willems WF, Pelzer M, et al Augmentation of surgical angiogenesis in vascularized bone allotransplants with host-derived a/v bundle implantation, fibroblast growth factor-2, and vascular endothelial growth factor administration. J Orthop Res. 2010;28(8):1015–1021. - PMC - PubMed
    1. Ren Q, Cai M, Zhang K, et al Effects of bone morphogenetic protein-2(BMP-2) and vascular endothelial growth factor (VEGF) release from polylactide-poly (ethylene glycol)-polylactide (PELA) microcapsule-based scaffolds on bone. Braz J Med Biol Res. 2017;51(2):e6520. - PMC - PubMed
    1. Schindeler A, McDonald MM, Bokko P, et al Bone remodeling during fracture repair: The cellular picture. Semin Cell Dev Biol. 2008;19(5):459–466. doi: 10.1016/j.semcdb.2008.07.004. - DOI - PubMed

Substances

LinkOut - more resources