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Review
. 2019 May;11(Suppl 2):S126-S130.
doi: 10.4103/JPBS.JPBS_41_19.

Platelet-Rich Plasma and Platelet-Rich Fibrin in Periodontal Regeneration: A Review

Sunil Paramel Mohan  1   2 , Nallusamy Jaishangar  3 , Sandha Devy  4 , Anjhana Narayanan  5 , Deepthi Cherian  5 , Sanupa Sethu Madhavan  5
Affiliations
Review

Platelet-Rich Plasma and Platelet-Rich Fibrin in Periodontal Regeneration: A Review

Sunil Paramel Mohan et al. J Pharm Bioallied Sci. 2019 May.

Abstract

Platelet concentrates (PCs; platelet-rich plasma and platelet-rich fibrin) are autologous bioactive substances that have found varied application in medical and dental fields, particularly in oral and maxillofacial surgery, plastic surgery, and sports medicine. The rationale of these technologies is to extract all the elements from patient's own blood sample, which could be used to improve healing by promoting tissue regeneration. PCs have evolved a long way since its introduction in 1954. PCs have been used successfully in periodontics and implant dentistry. However, the preparation protocol, processing time, transfer of concentrates, centrifugation temperature, vibration, etc., being not standardized are various factors for the mixed results reported in the literature. This review intends to discuss evolution of PCs, their preparation techniques, and their clinical and technical aspects and applications.

Keywords: Fibrin glue; leukocyte and platelet-rich fibrin; platelet concentrates; platelet-derived growth factors; platelet-rich fibrin; platelet-rich plasma; sticky bone.

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Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Structure of platelet (Courtesy: postgradmedj-2001-October-77-912-e6-F1.large)
Figure 2
Figure 2
Growth factors released from α granules and their function (Courtesy: researchgate.net). BMP = bone morphogenic protein, VEGF = vascular endothelial growth factor, PGDF = platelet-derived growth factor, TGF-β = transforming growth factor
Figure 3
Figure 3
Platelet concentrates (Courtesy: researchgate.net)
Figure 4
Figure 4
Layers obtained after centrifugation (Courtesy: www.naturaldentistassociates.com)
See this image and copyright information in PMC

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