Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 May;11(Suppl 2):S135-S139.
doi: 10.4103/JPBS.JPBS_56_19.

Gingival Crevicular Fluid: An Overview

Krishnan Chandragiri Subbarao  1 , Gowri Shankar Nattuthurai  1 , Satheesh Khannaa Sundararajan  1 , Indhu Sujith  1 , Jennifer Joseph  1 , Yasmin Parvin Syedshah  1
Affiliations
Review

Gingival Crevicular Fluid: An Overview

Krishnan Chandragiri Subbarao et al. J Pharm Bioallied Sci. 2019 May.

Abstract

Gingival crevicular fluid is an inflammatory exudate derived from the periodontal tissues. It is composed of serum and locally generated materials such as tissue breakdown products, inflammatory mediators, and antibodies directed against dental plaque bacteria. It plays a special part in maintaining the structure of junctional epithelium and the antimicrobial defense of periodontium. Some of the suspected periodontal pathogens such as Porphyromonas gingivalis and Treponema denticola produce broad-spectrum neutral proteinases as part of their virulence arsenal. These proteinases may be detected in plaque and gingival crevicular fluid samples of patients with periodontitis. The potential diagnostic importance of gingival fluid was recognized more than six decades ago. The fluid component of gingival crevicular fluid is derived primarily from microvascular (postcapillary venule) leakage. There are number of distinct advantages and challenges of using gingival crevicular fluid as a diagnostic test for periodontal disease.

Keywords: Exudate; leukocytes; periodontium.

PubMed Disclaimer

Conflict of interest statement

There are no conflicts of interest.

Figures

Figure 1
Figure 1
Mechanism of gingival crevicular fluid production
See this image and copyright information in PMC

Similar articles

See all similar articles

Cited by

See all "Cited by" articles

References

    1. Lamster IB. Evaluation of components of gingival crevicular fluid as diagnostic tests. Ann Periodontal. 1997;2:123–37. - PubMed
    1. Eley BM, Cox SW. Proteolytic and hydrolytic enzymes from putative periodontal pathogens: Characterization, molecular genetics, effects on host defenses and tissues and detection in gingival crevice fluid. Periodontol. 2000;2003(31):105–24. - PubMed
    1. Egelberg J. Permeability of the dento-gingival blood vessels: I. Application of the vascular labelling method and gingival fluid measurements. J Periodontal Res. 1966;1:181–91. - PubMed
    1. Weinstein E, Khurana H, Madel ID. Lactate dehydrogenase isoenzymes in gingival fluid. Arch Oral Biol. 1972;13:375–6. - PubMed
    1. Takamori K. The growth stimulating factors for lactobacillus appeared in tissue fluid from gingival crevice. Bull Tokyo Med Dent Univ. 1963;10:533.