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Review
. 2019 May 12;7(9):1523-1530.
doi: 10.3889/oamjms.2019.291. eCollection 2019 May 15.

Antierosive Effect of Topical Fluorides: A Systematic Review and Meta-Analysis of In Situ Studies

Ahmed Gamal Abdelwahed  1 , Marwa Mohamed Temirek  2 , Fayez Mohamed Hassan  3
Affiliations
Review

Antierosive Effect of Topical Fluorides: A Systematic Review and Meta-Analysis of In Situ Studies

Ahmed Gamal Abdelwahed et al. Open Access Maced J Med Sci. .

Abstract

Background: The effectiveness of the application of topical fluorides in prevention of erosive tooth wear has been an issue of controversy in the literature. The objective of this systematic review was to assess in situ studies investigating the effects of using topical fluorides on prevention of erosive tooth wear.

Material and methods: Two electronic databases PubMed/MEDLINE and Cochrane Central Register of Controlled Trials were searched. Eligibility criteria included in situ-controlled studies that assessed the effect of the erosive process without additional tooth brushing. The search involved English-written articles only. A total of 684 potentially relevant titles and abstracts were found after removal of duplicates, of which 22 full-text articles were selected. Seventeen studies were included in the qualitative synthesis of which 6 studies included in the meta-analysis. The following data were obtained for each study: authors, year of publication, country, study design, periods of study, duration, blinding, interventions (type/concentration/form), tooth substrate, location of the intraoral appliance, number of samples attached to each appliance, type of acidic media used for erosive challenge, duration of erosive challenge, subjects (number/age/sex), reported side effects -if any-, measuring device, amounts of tissue loss.

Results: The risk of bias of the included studies was assessed using the Cochrane Collaboration tool for assessing the risk of bias. A meta-analysis of the present study was performed using Comprehensive Meta-Analysis version 2.2.048 software.

Conclusion: The use of oral hygiene products containing AmF/NaF/SnCl2 or NaF may be effective in the prevention of erosive tooth wear.

Keywords: Erosive tooth wear; In situ; Topical fluoride.

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Figures

Figure 2
Figure 2
Risk of bias of included studies
Figure 3
Figure 3
Forest plot of fixed-effect meta-analysis for the amount of tissue loss after using Placebo and NaF Dentifrice (Enamel)
Figure 4
Figure 4
Funnel plot of meta-analysis for the amount of tissue loss after using Placebo and NaF Dentifrice (Enamel)
Figure 5
Figure 5
Forest plot of random-effects meta-analysis for the amount of tissue loss after using Placebo and NaF Solution (Enamel)
Figure 6
Figure 6
Funnel plot of meta-analysis for the amount of tissue loss after using Placebo and NaF Solution (Enamel)
Figure 7
Figure 7
Forest plot of random-effects meta-analysis for the amount of tissue loss after using Placebo and AmF/NaF/SnCl2 (Enamel)
Figure 8
Figure 8
Forest plot of fixed-effect meta-analysis for the amount of tissue loss after using NaF Solution and AmF/NaF/SnCl2 (Enamel)
Figure 9
Figure 9
Forest plot of fixed-effect meta-analysis for the amount of tissue loss after using Placebo and NaF Solution (Dentin)
Figure 10
Figure 10
Forest plot of fixed-effect meta-analysis for the amount of tissue loss after using NaF Solution and AmF/NaF/SnCl2 (Dentin)
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