Competing interests: Dr. Wood has been an advisory board member (with no compensation) for Astellas, Pfizer, and Novartis; and has participated in clinical trials supported by Aragon, AstraZeneca, BMS, Exelixis, Merck, Pfizer, and Roche. Dr. Kapoor has been an advisory board member for BMS, Eisai, Ipsen, Merck, Novartis, Pfizer, and Roche; a speakers bureau member for Eisai, Ipsen, Novartis, and Roche; and has received honoraria from BMS, Eisai, Ipsen, Merck, Novartis, Pfizer, and Roche. Dr. Basappa has been an advisory board member for Astellas, AstraZeneca, BI, BMS, Janssen, Novartis, and Pfizer; and has received honoraria from Astellas, BMS, Janssen, Novartis, and Pfizer. Dr. Cagiannos has been an advisory board member for Abbvie and Ferring; and has received honoraria from Abbvie, Acerus, and Ferring. Dr. Jewett has been an advisory board member for Pfizer and Theralase Tech; has received honoraria from Olympus, Pfizer, and Theralase Tech; and holds investments in Theralase Tech. Dr. Kassouf has received honoraria from Astellas, AstraZeneca, Janssen, Merck, and Roche. Dr. Kollmannsberger has been an advisory board member for Astellas, BMS, Novartis, Pfizer, and Sanofi; has received honoraria from BMS, Novartis, and Pfizer; and has participated in clinical trials supported by Astellas, AstraZeneca, BMS, Janssen, Merck, Novartis, Pfizer, and Sanofi. Dr. Lavallée has been an advisory board member for Ferring and Sanofi; and received a grant from Sanofi. Dr. Richard has been an advisory board member for Sanofi; and has received compenstaion from Abbvie, Astellas, and Janssen. Dr. So has been an advisory board member for Abbvie, Amgen, Astellas, Bayer, Ferring, Janssen, and Tersera; and has participated in clinical trials supported by Astellas, Ferring, and Janssen. Dr. Tanguay has been an advisory board member for Pfizer; and has received a travel grant from Sanofi. Dr. Rendon has been both an advisory board member and a speakers bureau member for and has received grants/honoraria from Abbvie, Amgen, Astellas, Astra Zeneca, Bayer, Ferring, Jansen and Sanofi Aventis. The remaining authors report no personal or financial conflicts related to this work.