Skip to main page content
U.S. flag

An official website of the United States government

Dot gov

The .gov means it’s official.
Federal government websites often end in .gov or .mil. Before sharing sensitive information, make sure you’re on a federal government site.

Https

The site is secure.
The https:// ensures that you are connecting to the official website and that any information you provide is encrypted and transmitted securely.

Access keys NCBI Homepage MyNCBI Homepage Main Content Main Navigation
Review
. 2019 Dec 15;145(12):3194-3206.
doi: 10.1002/ijc.32514. Epub 2019 Jun 28.

New perspectives on screening and early detection of endometrial cancer

Laura Costas  1 , Jon Frias-Gomez  1 , Magdalena Guardiola  1 , Yolanda Benavente  1   2 , Marta Pineda  3 , Miquel Á Pavón  1   4 , José M Martínez  5 , Maite Climent  5 , Marc Barahona  5 , Júlia Canet  3 , Sonia Paytubi  1 , Mónica Salinas  3 , Luis Palomero  6 , Ilaria Bianchi  7 , Jaume Reventós  8 , Gabriel Capellà  3   4 , Mireia Diaz  1   4 , August Vidal  4   9 , Josep M Piulats  4   10 , Álvaro Aytés  6 , Jordi Ponce  5 , Joan Brunet  3   4   11 , Francesc X Bosch  1   4 , Xavier Matias-Guiu  4   9 , Laia Alemany  1   2 , Silvia de Sanjosé  2   12 ; Screenwide Team
Affiliations
Review

New perspectives on screening and early detection of endometrial cancer

Laura Costas et al. Int J Cancer. .

Abstract

Due to the anatomical continuity of the uterine cavity with the cervix, genomic exploitation of material from routine Pap smears and other noninvasive sampling methods represent a unique opportunity to detect signs of disease using biological material shed from the upper genital tract. Recent research findings offer a promising perspective in the detection of endometrial cancer, but certain questions need to be addressed in order to accelerate the implementation of novel technologies in a routine screening or clinical setting. We discuss here new perspectives on detection of endometrial cancer using genomic and other biomarkers in minimally invasive sampling methods with a special focus on public health classic screening criteria, highlighting current gaps in knowledge.

Keywords: biomarkers; early detection; endometrial cancer; genomics; pap smears; screening.

PubMed Disclaimer

References

    1. Morice P, Leary A, Creutzberg C, et al. Endometrial cancer. Lancet 2016;387:1094-108.
    1. Wang Y, Li L, Douville C, et al. Evaluation of liquid from the Papanicolaou test and other liquid biopsies for the detection of endometrial and ovarian cancers. Sci Transl Med 2018;10:eaap8793.
    1. Andermann A. Revisiting Wilson and Jungner in the genomic age: a review of screening criteria over the past 40 years. Bull World Health Organ 2008;86:317-9.
    1. Ferlay J, Ervik M, Lam F, et al. GLOBOCAN 2018. Global cancer observatory: cancer today. Lyon, France: International Agency for Research on Cancer, 2018 Available from: https://gco.iarc.fr/today.
    1. Torre LA, Islami F, Siegel RL, et al. Global cancer in women: burden and trends. Cancer Epidemiol Biomarkers Prev 2017;26:444-57.

Publication types

Substances

LinkOut - more resources