Review

. 2019 Dec 15;145(12):3194-3206.

doi: 10.1002/ijc.32514. Epub 2019 Jun 28.

New perspectives on screening and early detection of endometrial cancer

Laura Costas¹, Jon Frias-Gomez¹, Magdalena Guardiola¹, Yolanda Benavente^{1

2}, Marta Pineda³, Miquel Á Pavón^{1

4}, José M Martínez⁵, Maite Climent⁵, Marc Barahona⁵, Júlia Canet³, Sonia Paytubi¹, Mónica Salinas³, Luis Palomero⁶, Ilaria Bianchi⁷, Jaume Reventós⁸, Gabriel Capellà^{3

4}, Mireia Diaz^{1

4}, August Vidal^{4

9}, Josep M Piulats^{4

10}, Álvaro Aytés⁶, Jordi Ponce⁵, Joan Brunet^{3

4

11}, Francesc X Bosch^{1

4}, Xavier Matias-Guiu^{4

9}, Laia Alemany^{1

2}, Silvia de Sanjosé^{2

12}; Screenwide Team

Affiliations

¹ Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
² Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Madrid, Spain.
³ Hereditary Cancer Program, IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.
⁴ Centro de Investigación Biomédica en Red en Cáncer (CIBERONC), Madrid, Spain.
⁵ Department of Gynecology and Obstetrics, Hospital Universitari de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
⁶ Program Against Cancer Therapeutic Resistance (ProCURE), IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.
⁷ ASSIR Delta, Direcció d'Atenció Primària Costa de Ponent, SAP Delta del Llobregat, Barcelona, Spain.
⁸ Departament de Ciències Bàsiques, Universitat Internacional de Catalunya, Barcelona, Spain.
⁹ Department of Pathology, Hospital Universitari de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
¹⁰ Department of Medical Oncology, IDIBELL, Catalan Institute of Cancer, Hospitalet de Llobregat, Barcelona, Spain.
¹¹ Medical Sciences Department, School of Medicine, University of Girona, Girona, Spain.
¹² PATH, Seattle, WA.

PMID: 31199503
DOI: 10.1002/ijc.32514

Review

New perspectives on screening and early detection of endometrial cancer

Laura Costas et al. Int J Cancer. 2019.

. 2019 Dec 15;145(12):3194-3206.

doi: 10.1002/ijc.32514. Epub 2019 Jun 28.

Authors

Affiliations

¹ Cancer Epidemiology Research Programme, Catalan Institute of Oncology, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
² Consortium for Biomedical Research in Epidemiology and Public Health (CIBER Epidemiología y Salud Pública, CIBERESP), Madrid, Spain.
³ Hereditary Cancer Program, IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.
⁴ Centro de Investigación Biomédica en Red en Cáncer (CIBERONC), Madrid, Spain.
⁵ Department of Gynecology and Obstetrics, Hospital Universitari de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
⁶ Program Against Cancer Therapeutic Resistance (ProCURE), IDIBELL, Catalan Institute of Oncology, Hospitalet de Llobregat, Barcelona, Spain.
⁷ ASSIR Delta, Direcció d'Atenció Primària Costa de Ponent, SAP Delta del Llobregat, Barcelona, Spain.
⁸ Departament de Ciències Bàsiques, Universitat Internacional de Catalunya, Barcelona, Spain.
⁹ Department of Pathology, Hospital Universitari de Bellvitge, IDIBELL, Hospitalet de Llobregat, Barcelona, Spain.
¹⁰ Department of Medical Oncology, IDIBELL, Catalan Institute of Cancer, Hospitalet de Llobregat, Barcelona, Spain.
¹¹ Medical Sciences Department, School of Medicine, University of Girona, Girona, Spain.
¹² PATH, Seattle, WA.

PMID: 31199503
DOI: 10.1002/ijc.32514

Abstract

Due to the anatomical continuity of the uterine cavity with the cervix, genomic exploitation of material from routine Pap smears and other noninvasive sampling methods represent a unique opportunity to detect signs of disease using biological material shed from the upper genital tract. Recent research findings offer a promising perspective in the detection of endometrial cancer, but certain questions need to be addressed in order to accelerate the implementation of novel technologies in a routine screening or clinical setting. We discuss here new perspectives on detection of endometrial cancer using genomic and other biomarkers in minimally invasive sampling methods with a special focus on public health classic screening criteria, highlighting current gaps in knowledge.

Keywords: biomarkers; early detection; endometrial cancer; genomics; pap smears; screening.

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New perspectives on screening and early detection of endometrial cancer

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New perspectives on screening and early detection of endometrial cancer

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