Review

. 2019 Jun 13;20(12):2892.

doi: 10.3390/ijms20122892.

Y Chromosome, Hypertension and Cardiovascular Disease: Is Inflammation the Answer?

Shanzana I Khan^{1

2}, Karen L Andrews^{3

4}, Garry L Jennings⁵, Amanda K Sampson⁶, Jaye P F Chin-Dusting^{7

8}

Affiliations

¹ Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia. shanzana.khan@monash.edu.
² Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. shanzana.khan@monash.edu.
³ Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia. karen@vividhomesolutions.com.au.
⁴ Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. karen@vividhomesolutions.com.au.
⁵ Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. garry.jennings@baker.edu.au.
⁶ Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. amanda.sampson@monash.edu.
⁷ Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia. jaye.chin-dusting@baker.edu.au.
⁸ Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. jaye.chin-dusting@baker.edu.au.

PMID: 31200567
PMCID: PMC6627840
DOI: 10.3390/ijms20122892

Review

Y Chromosome, Hypertension and Cardiovascular Disease: Is Inflammation the Answer?

Shanzana I Khan et al. Int J Mol Sci. 2019.

. 2019 Jun 13;20(12):2892.

doi: 10.3390/ijms20122892.

Authors

Shanzana I Khan^{1

2}, Karen L Andrews^{3

4}, Garry L Jennings⁵, Amanda K Sampson⁶, Jaye P F Chin-Dusting^{7

8}

Affiliations

¹ Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia. shanzana.khan@monash.edu.
² Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. shanzana.khan@monash.edu.
³ Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia. karen@vividhomesolutions.com.au.
⁴ Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. karen@vividhomesolutions.com.au.
⁵ Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. garry.jennings@baker.edu.au.
⁶ Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. amanda.sampson@monash.edu.
⁷ Department of Pharmacology, Monash University, Clayton, Victoria 3800, Australia. jaye.chin-dusting@baker.edu.au.
⁸ Baker IDI Heart and Diabetes Institute, Melbourne, Victoria 3004, Australia. jaye.chin-dusting@baker.edu.au.

PMID: 31200567
PMCID: PMC6627840
DOI: 10.3390/ijms20122892

Abstract

It is now becomingly increasingly evident that the functions of the mammalian Y chromosome are not circumscribed to the induction of male sex. While animal studies have shown variations in the Y are strongly accountable for blood pressure (BP), this is yet to be confirmed in humans. We have recently shown modulation of adaptive immunity to be a significant mechanism underpinning Y-chromosome-dependent differences in BP in consomic strains. This is paralleled by studies in man showing Y chromosome haplogroup is a significant predictor for coronary artery disease through influencing pathways of immunity. Furthermore, recent studies in mice and humans have shown that Y chromosome lineage determines susceptibility to autoimmune disease. Here we review the evidence in animals and humans that Y chromosome lineage influences hypertension and cardiovascular disease risk, with a novel focus on pathways of immunity as a significant pathway involved.

Keywords: immune-mediated hypertension; sex differences; vascular dysfunction.

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Conflict of interest statement

The authors declare no conflict of interest.

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Y Chromosome, Hypertension and Cardiovascular Disease: Is Inflammation the Answer?

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Y Chromosome, Hypertension and Cardiovascular Disease: Is Inflammation the Answer?

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