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Meta-Analysis
. 2019 Jun 14;19(1):144.
doi: 10.1186/s12872-019-1071-x.

Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention

Xiao-Tao Zhao  1 , Chun-Fei Zhang  2 , Qing-Jie Liu  3
Affiliations
Meta-Analysis

Meta-analysis of Nicorandil effectiveness on myocardial protection after percutaneous coronary intervention

Xiao-Tao Zhao et al. BMC Cardiovasc Disord. .

Abstract

Background: Using the current meta-analysis as well as systematic review, to determine the curative effect of Nicorandil in comparison of no Nicorandil after elective percutaneous coronary intervention(PCI) on patients.

Methods: Published literatures were identified via a computerized literature search of CENTRAL, PubMed, Cochrane, Embase Databases of Systematic Reviews. A set of randomized trials evaluating Nicorandil in comparison of no Nicorandil administered following PCI in patients harboring coronary artery disease were included. Outcomes were revealed based on the following parameters: peak creatine kinase-MB (CK-MB) value, left ventricular ejection fraction (LVEF), peak troponin I (cTnI), and major adverse cardiovascular events (MACEs) per randomized patients.

Results: We included a total of 14 RCTs involving 1864 subjects in the present review. According to this meta-analysis, LVEF was significantly improved in Nicorandil group; the peak CK-MB level and the incidence of adverse cardiovascular events were remarkably lower in Nicorandil group. Nicorandil and no Nicorandil administered group appeared to be equivalent with regards to cTnI.

Conclusions: Nicorandil is effective for patients undergoing elective PCI with coronary artery disease in terms of reducing the incidence of adverse cardiovascular events as well as improving heart function. Nicorandil may exert potential role as a valid and adjunctive therapy accompanied with PCI.

Keywords: Acute myocardial infarction; Angina; Cardiovascular events; Coronary artery disease; Heart function; Meta-analysis; Nicorandil; Percutaneous coronary intervention.

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Conflict of interest statement

The authors declare that they have no competing interests.

Figures

Fig. 1
Fig. 1
Flow diagram of search strategy of study
Fig. 2
Fig. 2
Methodological quality assessment for each included study
Fig. 3
Fig. 3
Comparison of the cardiac function between Nicorandil group and no Nicorandil group
Fig. 4
Fig. 4
Comparison of myocardial injury indexes between Nicorandil group and no Nicorandil group
Fig. 5
Fig. 5
Comparison of major adverse cardiovascular events between Nicorandil group and no Nicorandil group
See this image and copyright information in PMC

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